Thermo Scientific CellInsight CX7 LZR High Content Confocal Analysis Platform with Orbitor RS2 Automated Microplate Mover

The Thermo Scientific CellInsight CX7 LZR combined with the Orbitor RS2 Microplate Mover is a comprehensive high-content confocal analysis system engineered for automated, high-throughput cellular imaging and screening applications. It integrates laser-based confocal and widefield fluorescence optics with advanced robotic plate handling to enable continuous, unattended multiwell plate processing, widely used in molecular diagnostics, drug discovery, and biotechnology research.

Key technical features include:

• Confocal and widefield imaging with a 7-color laser light engine (405, 450, 488, 561, 594, 647, 785 nm) for multiplex fluorescence excitation and a white LED for brightfield imaging.
• Infinity-corrected optical system with selectable confocal pinholes (40 µm and 70 µm) optimizing optical sectioning and image resolution.
• Motorized 3-position objective turret accommodating Olympus 10x NA 0.40, 20x NA 0.45, and 40x NA 0.60 lenses, supporting sub-micron focus steps for precise cellular detail imaging.
• Automated Orbitor RS2 Microplate Mover featuring a robotic gripper with a payload capacity of 320 g, supporting clear-bottom multiwell plates (96, 384, 1536 wells) and glass slides (up to 4), with barcode reader compatibility for robust sample tracking.
• Advanced motorized stage and finely-tuned autofocus enabling high reproducibility and throughput essential in phenotypic screening, cellular assay development, and bioprocessing pipelines.
• Integrated barcode reading supporting a broad range of symbologies (UPC, EAN, Code 39/128, Data Matrix), facilitating sample identification in automated workflows.
• Supplied with dedicated high-content screening software (HCS Studio) and a control PC for instrument operation and data acquisition.
• Comprehensive system testing including illumination exposure calibration, autofocus validation, mechanical motion control, objective switching accuracy, and software communication checks performed to ensure imaging fidelity critical for synthetic biology and molecular biology research.

This platform is crucial for applications requiring high-content cell imaging with confocal resolution, including:

• Drug discovery and pharmaceutical screening assays.
• Live-cell and fixed-cell fluorescence biomarker analysis.
• High-throughput phenotypic and morphological studies in clinical diagnostics.
• Automated imaging integration with robotic screening systems in biomanufacturing and gene editing workflows.
• Quantitative fluorescence analysis for cell health, viability, and synthetic biology experiments.

The inclusion of the Orbitor RS2 robotic microplate mover extends the platform’s capability for unattended operation by enabling sequential access to multiple plate stacks (up to 3 stacks, ~40 plates per stack), aligning with the demands of modern biotechnological laboratories engaged in gene editing and molecular cloning workflows.

This turnkey system is supported by a 120-day US warranty and 60-day international warranty, with optional extended service agreements. It has been fully serviced, tested for operation, and certified functional, ensuring reliability and performance for integration into advanced biomedical engineering and biotechnology research environments.

Keywords: high content confocal microscope, CellInsight CX7 LZR, automated microplate mover, laser fluorescence imaging, multiplex cellular analysis, high-throughput screening platform, phenotypic screening system, molecular diagnostics instrument, synthetic biology imaging, bioprocessing automation, confocal imaging for biotechnology, pharmaceutical screening microscope.