Thermo Scientific CellInsight CX7 LZR Pro High Content Confocal Analysis Platform

The Thermo Scientific CellInsight CX7 LZR Pro is a cutting-edge high content confocal analysis platform tailored for automated cellular imaging and multiplexed fluorescence detection. Designed for advanced biotechnology and molecular diagnostics workflows, this system integrates confocal and widefield optics to enable detailed phenotypic screening and 3D cell model visualization.

Key technical specifications include:

• *Imaging capabilities*: Widefield, Brightfield, and Confocal modalities with laser-based autofocus
• *Camera*: Photometrics high-resolution fluorescent sCMOS camera cooled to -20°C with >95% quantum efficiency for enhanced sensitivity and 16-bit, 65,356 greyscale detection levels
• *Optics*: Infinity corrected optical system with a 3-position objective changer (10x/0.40 UPlanXApo, 20x/0.45 LUCPlanFL N, 40x/0.60 LUCPlanFL N)
• *Confocal pinholes*: 40 µm and 70 µm for variable depth resolution and optical sectioning
• *Illumination*: Laser-based light engine housing seven Class 3B lasers spanning 405 nm to 785 nm with accompanying White, Amber, Red, Green, and Blue LEDs for brightfield imaging
• *Automation*: Automated plate handling compatible with clear bottom 96-, 384-, and 1536-well microplates as well as up to 4 glass microscope slides with adapters
• *Focus control*: Sub-micron step size micro-stepping and double stepping, laser autofocus for rapid, precise focusing across wells and varying sample heights
• *Barcode reading*: Supports multiple symbologies including UPC-A, EAN, Code 39, and USS-128 for streamlined sample tracking
• *Software*: Comes with HCS Studio for data acquisition and analysis, optimized for high-throughput screening

This platform is widely adopted in biotechnology research, molecular diagnostics, and drug discovery programs involving cell signaling, toxicity screening, organoid, and 3D cell model imaging. The integration of a laser autofocus system combined with a sensitive sCMOS camera expands assay capabilities by reducing exposure times and speeding image acquisition, making it critical in biopharmaceutical production pipelines and synthetic biology research applications.

Customizable environmental options and remote instrument setup are available, ensuring adaptability to diverse laboratory needs. The instrument undergoes thorough pre-shipment validation, including optics alignment, software functionality, autofocus precision, and mechanical controls optimization, guaranteeing reliable operation in demanding clinical diagnostics and live-cell imaging environments.

This high content confocal microscope system is indispensable for researchers requiring automated, multiplexed analysis with superior imaging quality in neuroimaging, cell biology, and bioprocessing laboratories.