Thermo Scientific CellInsight CX7 HCS High Content Screening Platform Unit 3

The Thermo Scientific CellInsight CX7 HCS High Content Screening Platform Unit 3 is a versatile automated imaging system designed for high-throughput biological sample analysis in cell biology, molecular diagnostics, and bioprocessing research. It integrates fluorescence, brightfield, and confocal imaging modalities, supporting complex cell-based assays essential in biotechnology applications such as gene editing validation, phenotypic profiling, and drug discovery screening.

Key technical features include:

• Optical configuration: Infinity-corrected optical system with Olympus objectives (10x NA 0.40, 20x NA 0.45, 40x NA 0.6) on an automated 3-position objective changer
• Illumination sources:
• Widefield: 7-color high-output LED covering excitation wavelengths at 405, 450, 488, 561, 594, 647, and 785 nm, enabling multiplexed fluorescence assays
• Brightfield: RGB and amber LED array plus white light for enhanced contrast imaging
• Confocal: Crest Optics spinning disk with 10,000 RPM pinhole disks (40µm and 70µm) for high-resolution optical sectioning
• Imaging capabilities: Supports multi-well plates (clear bottom 96-, 384-, and 1536-well formats) and up to 4 glass microscope slides with adapter, accommodating diverse high-content screening workflows
• Precision focusing: Sub-micron focus step size with advanced micro-stepping and double-stepping for accurate z-positioning critical for 3D cell imaging and live-cell experiments
• Barcode reading: Integrated reader supporting multiple symbologies for sample tracking and laboratory automation
• Software: Comes with HCS Studio 5 software for image acquisition, high-throughput data visualization, and quantitative analysis, essential for molecular biology and synthetic biology research pipelines
• Automation options: Compatible with Orbitor RS2 microplate mover for enhanced throughput and workflow integration in biomanufacturing and pharmaceutical screening settings
• Application domains: Widely used for drug discovery, RNAi or CRISPR screening, phenotypic cellular profiling, and quantitative fluorescence analysis in biomedical engineering and molecular diagnostics
• Warranty and support: Includes 120 days continental US warranty, 60 days international, with remote instrument setup, training, and after-sales technical support; validated for full operational functionality by certified technical service team

This platform is well-suited for biotechnology professionals involved in gene editing validation, live-cell imaging assays, and molecular cloning workflows, offering robust, reproducible imaging with high spectral flexibility. The combination of widefield, brightfield, and confocal imaging modes makes the CellInsight CX7 a critical tool in synthetic biology research and phenotypic screening critical to biopharmaceutical production pipelines.

Its configuration supports expansive fluorescence spectral ranges and multi-mode imaging protocols, providing a powerful solution for researchers performing complex mechanistic studies, quantitative cell-based assays, and high-throughput screening essential in translational medicine and bioprocess development. The system's adaptability for various microplate formats and slides further enhances its utility in diverse laboratory environments.

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