Illumina Infinium Methylation Assay

Illumina Infinium is a versatile microarray platform designed for high-throughput genomic and epigenomic analyses, enabling researchers to detect genetic and epigenetic variations with exceptional accuracy.

Key features:

• Flexible content: Offers predesigned arrays with expert-selected content, with options to add or create custom arrays tailored to specific research needs.
• Pretested content: Provides optimised and tested content across numerous genetic disease research areas.
• Multiple applications: Supports a broad range of applications, including genotyping, copy number variation and cytogenetic analysis, genome-wide and epigenome-wide association studies, and more.
• High data quality: Delivers average call rates exceeding 99%, reproducibility of ≥ 99.9%, high signal-to-noise ratios, and low overall noise levels.
• Cost-effective solution: Interrogates numerous single nucleotide polymorphisms (SNPs) or CpGs at a low total running cost.
• Low DNA input: Requires a minimal DNA sample input of 100–200 ng, sufficient to assay millions of loci.

Applications:

• Genotyping: Identifying genetic variants associated with disease risk in large cohorts or populations.
• Epigenomics: Profiling DNA methylation patterns to study gene regulation and expression.
• Pharmacogenomics: Investigating how genetic variations affect drug response to inform precision medicine.
• Genome-wide association studies (GWAS): Discovering and characterising genetic variants linked to diseases.

Commonly used in:

• University laboratories
• Biomedical research centres
• Clinical environments

Since its introduction, the Illumina Infinium platform has been widely adopted and remains a cornerstone in genomic research, continually evolving to meet the demands of modern biotechnology applications.