Affymetrix GeneChip Human Genome U133A Array

Affymetrix U133A is a pioneering gene expression microarray designed to analyse the expression profiles of over 14,500 well-characterised human genes. This microarray enables researchers to explore human biology and disease processes comprehensively.

Key features include:

• Comprehensive Coverage: Analyses the expression levels of 18,400 transcripts and variants, encompassing 14,500 well-characterised human genes.
• High Probe Density: Comprises over 22,000 probe sets and 500,000 distinct oligonucleotide features, ensuring detailed and accurate gene expression analysis.
• Enhanced Sensitivity: Utilises multiple independent measurements for each transcript, delivering superior accuracy and reproducibility compared to other microarray platforms.
• Reduced Sample Requirements: The updated design with reduced feature size allows for smaller sample volumes without compromising performance.

This microarray is widely applied in:

• Molecular Biology: Investigating gene expression patterns and regulatory mechanisms.
• Biomedical Research: Identifying disease biomarkers and understanding pathogenesis.
• Pharmacogenomics: Assessing drug responses and personalising treatments.

Commonly utilised in:

• University Laboratories: Conducting fundamental and applied research in genetics and genomics.
• Biomedical Research Centres: Exploring disease mechanisms and therapeutic targets.
• Clinical Research Facilities: Developing diagnostic tools and personalised medicine approaches.

Introduced in the early 2000s, the Affymetrix U133A microarray has been instrumental in advancing gene expression studies. While newer technologies have emerged, this microarray remains a valuable resource in many research settings.