Wyatt DynaPro PlateReader III WPR3-02 - Automated Multi-Well Dynamic Light Scattering System

The Wyatt DynaPro PlateReader III WPR3-02 is a high-throughput dynamic light scattering (DLS) and static light scattering (SLS) platform engineered for advanced nanoparticle and protein characterization directly in industry-standard microwell plates (96-, 384-, 1536-well). This instrument performs in situ measurements eliminating the need for fluid transfer, enhancing reproducibility and speed in biotherapeutic formulation, nanoparticle sizing, and protein aggregation analysis.

Key technical features include:

• Nanoparticle size range (hydrodynamic radius, Rh by DLS): 0.5 to 1000 nm, enabling detection across a broad particle size distribution critical for biopharmaceutical and nanomedicine research.
• Molar mass range by SLS: 1000 Da to 1 MDa (dependent on molecular conformation), ideal for monitoring macromolecular complexes and protein oligomerization states essential in synthetic biology and molecular diagnostics.
• Sample Volume: Minimum 4 µL compatible with high-density 1536-well plates, facilitating bioprocessing workflows requiring minimal sample consumption.
• Laser specifications: 830 nm wavelength with programmable power control (10% to 100%) to optimize signal-to-noise ratio for fluorescence-free scattering measurements.
• Temperature control: Range from 4 to 85 °C supports thermal stability assays and protein crystallization studies critical to biotechnology and biomanufacturing pipelines.
• Software: Dynamics v8.0.0.89 included (non-21 CFR 11 compliant), supporting detailed data analysis for molecular stability, aggregation kinetics, and formulation screening.

The PlateReader III is widely adopted in biotechnological research fields including drug discovery, molecular diagnostics, gene editing vector characterization, and biopharmaceutical production pipelines. Its ability to rapidly analyze high sample volumes with precise thermal and fluidic control makes it essential for molecular cloning workflows, protein engineering, and nanoparticle formulation optimization. The system includes a 9mm plate insert, 7.5mm plate hardware kit, nitrogen purge connector, and is delivered with a laptop preloaded with Dynamics software.

Overall, this platform enhances productivity in fluorescence-free dynamic light scattering assays indispensable for protein stability profiling, AAV vector titer determination, and high-throughput screening in biomedical engineering and synthetic biology research. Shipping is available worldwide for global biotechnology research environments.