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Wyatt DynaPro PlateReader III Dynamic & Static Light Scattering Instrument WPR3-01

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Wyatt Technology
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Used
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Product description

Automated DLS/SLS plate reader for nanoparticle size 0.5–1000 nm and protein aggregation in microwell plates.

The Wyatt DynaPro PlateReader III WPR3-01 is a high-throughput, automated dynamic and static light scattering (DLS/SLS) system optimized for nanoparticle sizing and protein aggregation analysis directly in industry-standard microwell plates (96-, 384-, or 1536-well). Ideal for biotherapeutic formulation, molecular diagnostics, and nanoparticle characterization workflows, it enables *in situ* measurements with minimal sample volume (down to 4 µL), eliminating fluid transfer and sample carryover.

Key technical features include:

  • Nanoparticle size range (hydrodynamic radius by DLS): 0.5 to 1000 nm
  • Molar mass range (by static light scattering): 1,000 Da to 1 MDa (dependent on conformation)
  • Sensitivity: 0.125 mg/mL using lysozyme (14.4 kDa)
  • Laser wavelength: 830 nm with programmable laser power (10% to 100%)
  • Temperature control: Integrated 4°C to 85°C for thermal stability and denaturation studies
  • Sample compatibility: Supports disposable microwell plates ideal for high-throughput bioprocessing and protein crystallization screening

This instrument is widely adopted in biotechnology and biopharmaceutical research, providing critical support for synthetic biology, gene editing vector analysis, and biomanufacturing process development. Its robust software suite (Dynamics v7.8.1.3) facilitates efficient data acquisition and analysis, although it does not include 21 CFR Part 11 compliance security options.

Applications encompass:

  • Protein aggregation and oligomerization studies
  • Viral and non-viral gene vector characterization, including AAV titer analysis
  • Formulation screening and stability testing for biotherapeutics
  • Optimization of protein crystallization
  • Screening for reversible self-association and viscosity behavior in high-concentration proteins

The DynaPro PlateReader III is essential for molecular diagnostics laboratories and research groups focusing on nanoparticle-based drug delivery, live-cell assay development, and fluorescence-free analytical methods. Designed to improve throughput and reproducibility, it is an indispensable tool for bioprocessing workflows, providing precise and reproducible nanoparticle and macromolecular characterization critical to modern biotechnology and clinical diagnostics.

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Frequently asked questions

How long does laboratory equipment typically last?

With a service contract, ten to fifteen years is normal for most benchtop instruments. Detectors and pumps are the parts that wear first.

Can I get service for older equipment?

Often, yes. Verified suppliers frequently work with service partners converting the instrument. If applicable, we can list servicing options alongside the offer.

Where can I buy parts?

Ask a scientist through the request button. Parts are often available even when the instrument itself is discontinued.

What is the typical lead time for refurbished equipment?

Two to six weeks, depending on refurbishment scope and whether calibration is included.

Does laboratory equipment ship internationally?

We ship to 38 countries. Crating and customs handling are quoted with the instrument.

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Last updated 22 October 2026