Wyatt DynaPro PlateReader III WPR3-01 Dynamic Light Scattering and Static Light Scattering Instrument

The Wyatt DynaPro PlateReader III WPR3-01 integrates high-throughput automated dynamic light scattering (DLS) and static light scattering (SLS) techniques for precise nanoparticle sizing and protein aggregation analysis critical in biotechnology, molecular diagnostics, and biopharmaceutical development. Designed for simultaneous screening in industry-standard 96-, 384-, or 1536-well microwell plates, this instrument performs in situ measurements without fluid transfer, ensuring sample integrity and efficiency in workflows such as protein crystallization optimization and biotherapeutic formulation screening.

Key technical features include:

• Nanoparticle size detection range: 0.5 to 1000 nm (hydrodynamic radius by DLS), enabling detailed analysis of proteins, polymers, and nanoparticles essential in synthetic biology and gene editing research.
• Molar mass detection by SLS: 1000 Da to 1 MDa, facilitating characterization of biomolecules in molecular cloning and bioprocessing pipelines.
• Sensitivity: Detects lysozyme at concentrations as low as 0.125 mg/mL, suitable for monitoring aggregation and stability of biologics.
• Sample volume minimum: Only 4 µL required using 1536-well plates, optimizing throughput and conserving precious samples used in cell imaging and clinical diagnostics.
• Optical system: 830 nm laser with programmable power control (10–100%) tailored for fluorescence-compatible assays and minimizing photodamage.
• Temperature control: Range of 4 to 85 °C, critical for stability assessments in biomanufacturing and thermal screening of biomolecules.

This unit is sold as parts only, with operational laser and camera functions; however, the Peltier heating/cooling system is non-functional due to power issues. It is ideal for repair, refurbishment under a Wyatt service contract, or as a spare for existing DynaPro PlateReader III users.

The instrument package includes the DynaPro PlateReader III, a 9 mm plate insert, digital user manual, and N2 connector with tubing.

This advanced light scattering system is widely adopted in synthetic biology research, providing essential data for nanoparticle characterization and molecular diagnostics, and is critical in biopharmaceutical production pipelines demanding robust, high-throughput analytical tools.