Leica RM2255 Motorized Rotary Microtome for Precision Tissue Sectioning

The Leica RM2255 is a motorized rotary microtome designed for precise and reproducible tissue sectioning, essential in histology, molecular diagnostics, and biomedical research workflows including bioprocessing and synthetic biology applications.

• Features a motorized coarse feed system with stepper motor control inside a dustproof plastic housing ensuring long-term reliable operation.
• Specimen feed incorporates zero-backlash, maintenance-free cross roller guides for exact positioning with 28 mm ±1 mm travel; vertical stroke is 70 mm.
• Section thickness adjustable from 0.50 to 100 μm in precise increments tailored for various research needs:
• 0.5 to 5.0 μm in 0.5 μm steps
• 5.0 to 20.0 μm in 1.0 μm steps
• 20.0 to 60.0 μm in 5.0 μm steps
• 60.0 to 100.0 μm in 10 μm steps
• Trimming thickness range from 1 to 600 μm with variable increments suitable for preparing thicker sections or trimming blocks.
• Offers three motorized sectioning modes (continuous, single, step) and a manual rocking mode for flexibility and precise control during sample preparation.
• Integrated specimen retraction adjustable or disabled, reducing knife wear and sample damage, varying with sectioning speed in motorized mode.
• Safety features include a lockable handwheel with centered handle and a separate control panel with logically arranged buttons and LED indicators.
• Sectioning speeds range from 0.5 to 420 mm/s with ±10% accuracy, supporting various throughput and section quality requirements.
• Maximum specimen size accommodated is 50 x 60 x 40 mm with ±8° orientation adjustment in both horizontal and vertical axes, optimizing diverse sample geometries.
• Precision repositioning of the knife holder base allows ±24 mm north-south and ±23 mm east-west adjustments for exact blade positioning.
• Compact dimensions (413 x 618 x 305 mm) and moderate weight (37 kg) facilitate integration into standard laboratory benches.

This motorized rotary microtome is widely adopted in biotechnology laboratories, clinical diagnostics, and biomanufacturing settings, playing a critical role in molecular cloning workflows, synthetic biology research, and tissue histopathology. The RM2255 supports advanced tissue sectioning essential for fluorescence analysis, live-cell imaging preparations, and neuroimaging specimen processing.