Covaris ME220 Focused Ultrasonicator Unit 3 – Benchtop AFA Acoustic Sample Prep System

The Covaris ME220 Focused Ultrasonicator Unit 3 is a benchtop acoustic sample preparation system employing Adaptive Focused Acoustics (AFA) technology, designed for precise and reproducible ultrasonic processing of biological samples. This model supports flexible sample throughput, processing from 1 to 8 samples simultaneously depending on tube configuration, with sample volumes ranging from 15 µL to 4 mL.

Key technical features include:

• AFA technology enabling controlled DNA/RNA/chromatin shearing, tissue homogenization, and efficient cell lysis (mammalian, bacterial, yeast).
• Integrated automated water bath with programmable temperature control from +6 °C to +40 °C, supported by a solid-state chiller for precise heating and cooling.
• Adjustable treatment power ranging from 2.5 to 75 Watts peak incident power and 0.1 to 20 Watts average incident power, ensuring adaptable ultrasonic intensity for diverse protocols.
• Compatible consumables include milliTUBE, microTUBE, microTUBE Strip, and miniTUBE racks, allowing workflow flexibility for molecular diagnostics, bioprocessing, and synthetic biology research.
• Compact footprint and low noise operation optimize lab space usage and improve user experience during extended runs.
• SonoLAB software interface facilitates method programming and remote instrument setup, supporting protocol reproducibility critical in molecular cloning and biomanufacturing pipelines.

Applications encompass cfDNA extraction from plasma, DNA extraction from dried blood spots and FFPE samples, total nucleic acid and protein extraction, and critical tissue lysis workflows. The instrument’s precise acoustic control is essential for biotechnology fields including molecular diagnostics, gene editing sample prep, and biopharmaceutical production pipelines.

Included with the unit: the Covaris ME220 ultrasonicator, a dedicated computer with SonoLAB software, and communication/power cables. Consumables such as tube racks and waveguides are application-specific and must be sourced separately.

This fully serviced unit offers a 120-day US warranty and 60-day international warranty, with options for remote training and technical consultation. The ME220 is widely adopted in research environments demanding high-throughput ultrasonic sample preparation with consistent, reproducible results for downstream analysis in genomics, epigenetics, and cell imaging studies.