Covaris LE220-Plus Focused Ultrasonicator System for High-Throughput DNA/RNA Sample Processing

The Covaris LE220-Plus is an advanced, scalable focused ultrasonicator system designed for high-throughput processing of DNA and RNA samples, supporting up to 96 simultaneous samples in volumes ranging from 5 to 500 µL. It streamlines whole-genome PCR-free workflows by eliminating up to 80% of shearing steps and reducing NGS library preparation time by 30%.

Key technical features include:

• Precise acoustic energy delivery with treatment power adjustable between 2.5 to 500 Watts Peak Incident Power and 0.1 to 250 Watts Average Incident Power.
• Automatic water level detection and z-height adjustment to ensure consistent Adaptive Focused Acoustics (AFA) performance essential in molecular diagnostics and bioprocessing.
• Integrated SonoLab software enables remote startup, scheduling, and protocol management, enhancing workflow automation critical in synthetic biology and biopharmaceutical production pipelines.
• Non-contact sample processing reduces contamination risk, ideal for processing diverse sample types such as DNA, plasma, chromatin, fresh and dried blood spots.
• Compliance with international safety and electromagnetic compatibility standards (CE, ETL, WEEE, IEC/EN/ANSI/UL 61010-1, EU EMC Directive 2014/30/EU, FCC Part 15 Class A).
• Requires ThermoCube and WCS 2.0 chiller systems for operation, allowing integration with existing laboratory automation platforms.

This system is widely adopted in genomics and molecular biology research, offering robustness and reproducibility for critical biotechnological workflows, including sample preparation for next-generation sequencing (NGS), gene editing, and molecular cloning. Its compatibility with existing Covaris protocols makes it a flexible choice for enhancing efficiency in clinical diagnostics and biomedical engineering labs focused on large-scale nucleic acid processing.