Molecular Devices ImageXpress Micro 4 Automated High Content Imaging System with sCMOS Camera

The Molecular Devices ImageXpress Micro 4 is an advanced automated widefield fluorescence high content imaging system optimized for high-throughput screening and phenotypic profiling in multi-well plate assays. Equipped with a high-sensitivity Andor Zyla sCMOS camera, it delivers fast image acquisition speeds exceeding 200,000 wells per day at 10x magnification, essential for large-scale biotechnology and molecular diagnostics workflows.

Key features include:

• Motorized optics with a 4-position objective changer supporting Nikon Plan Fluor and Plan Apo Lambda objectives (4x, 10x, 20x, 40x) enabling flexible magnification from low to high power.
• An integrated 5-position fluorescence filter changer (filters not included), capable of up to 5 illumination channels for multiplexed fluorescence detection, critical in synthetic biology and live-cell imaging applications.
• Combined laser and image autofocus systems for precise focusing on multi-well plates up to 1536 wells, facilitating reliable cell counting, drug discovery assays, and disease modeling.
• Phase contrast capability with ELWD condenser inserts and multiple transmitted light modalities (brightfield with GIF, D, NCB, and ND filters) for label-free cell imaging and morphology studies.
• Supports high-throughput screening workflows with plate scan times as fast as 2 minutes for a 96-well plate with two fluorescence channels at one site per well.
• Compatible with environmental controls including temperature and CO₂ mixing modules (optional, not included), enabling live-cell time-lapse imaging in biomedical engineering and stem cell research contexts.
• Robotics- and automation-friendly design for integration into bioprocessing and biomanufacturing pipelines, supporting efficient operation in molecular biology labs and clinical diagnostic settings.

The system requires Molecular Devices’ MetaXpress software for full functional operation and image analysis, which must be acquired separately. It comes with essential power supply, Lumencor Sola LED light engine for consistent fluorescence excitation, and all necessary cables (excluding the light source cable).

Widely adopted in biotechnology research fields such as infectious disease, oncology, and toxicology, this system supports advanced applications including neurite outgrowth analysis, cardiomyocyte imaging, and 3D cell model phenotyping, making it critical for gene editing and synthetic biology studies.

This unit is sold as-is with no warranty or returns due to the inability to perform full software-driven testing. Customers are encouraged to verify operational suitability and obtain MetaXpress licenses before deployment. The ImageXpress Micro 4 delivers reliable, high-quality imaging for comprehensive cellular assays and is popular among molecular biology researchers focusing on fluorescence analysis and live-cell imaging.