Molecular Devices ImageXpress Micro 4 High Content Imaging System with sCMOS Camera and Automated Optics

The Molecular Devices ImageXpress Micro 4 is an automated high content imaging system designed for rapid, high-resolution microscopy of multi-well plates and slides, widely used in biotechnology, cell imaging, and molecular diagnostics research. It utilizes an Andor Zyla sCMOS camera to deliver a high signal-to-noise ratio and rapid image acquisition speed exceeding 200,000 wells per day.

Key technical features include:

• Four-position motorized objective turret supporting Nikon objectives: Plan Fluor 10x/0.30, S Plan Fluor ELWD 40x/0.60, Plan Apo Lambda 4x/0.20, and Plan Apo Lambda 20x/0.75.
• Five-position motorized filter changer, enabling up to five fluorescence illumination channels (filters not included), supporting multiplexed fluorescence detection critical for gene editing and bioprocessing workflows.
• Laser- and image-based autofocus systems improve throughput and reliability in high-content assays.
• Phase contrast capabilities with ELWD 0.3 phase contrast wheel including PHL 1 and 2 condenser inserts for label-free live cell visualization.
• Brightfield transmitted light path with GIF, D, NCB, and ND brightfield filters for versatile imaging modalities.
• Compatible with plates up to 1536 wells, suitable for high-throughput screening, phenotypic profiling, and drug discovery.
• Robotics and automation compatibility support integration into biomanufacturing and automated synthetic biology platforms.
• Environmental control options for temperature and CO₂ regulation enable live-cell imaging and cell migration assays.
• Typical scan time for a 96-well plate with two fluorescence colors and one site per well is approximately 2 minutes, supporting accelerated workflows in oncology research, stem cell studies, and infectious disease modeling.

This instrument is ideal for labs conducting advanced cell-based assays, including 3D cell model imaging, neurite outgrowth analysis, and toxicology studies. The system’s modular design facilitates customization of optical paths and filter sets, making it robust for diverse molecular and cellular biology applications.

Note: This listing excludes the light source cable and requires separate purchase of the MetaXpress software license from Molecular Devices for full operation and testing. The instrument is offered as-is with power-on verification only.

This system supports key biotechnology research fields such as molecular cloning workflows, biopharmaceutical production pipelines, and clinical diagnostics, with high-speed imaging capabilities essential for modern bioprocessing and synthetic biology research environments.