Waters Acquity Xevo TQ Mass Spectrometer System

The Waters Xevo TQ Mass Spectrometer is an advanced benchtop, tandem quadrupole mass spectrometer engineered for ultra-high performance LC/MS/MS applications. Unlike traditional setups, it implements innovative T-Wave and ScanWave-enabled collision cell technology, enabling a versatile instrument adept at supporting both quantitative and qualitative analyses on a single MS platform. Designed as a robust solution for quantitative LC/MS/MS, it features high-speed MRM (Multiple Reaction Monitoring) alongside enhanced full-scan spectral acquisition modes for superior qualitative analysis.

The system includes IntelliStart Technology to automate system optimization and status monitoring, ensuring exceptional data quality consistently accessible by operators at any experience level.

Acquisition modes include:

• Full scan MS
• Product ion scan (ScanWave enhanced)
• Precursor ion scan
• Constant neutral loss
• Selected ion recording (SIR)
• Multiple reaction monitoring (MRM)

Survey scan modes provide:

• Full scan MS triggered product ion scan
• Precursor ion scan triggered product ion scan
• Constant neutral loss triggered product ion scan

Quan Qual mode provides MRM-triggered, ScanWave-enhanced product ion spectral acquisition.

The mass range spans 2 to 2048 m/z, with scan speeds reaching up to 10000 Da/s. Achievable acquisition rates include 10 scans per second (100 to 1000 m/z) and 20 scans per second (50 to 500 m/z), with mass stability showing less than 0.1 amu drift over 24 hours. Linearity of response covers five orders of magnitude from the limit of detection for a specified compound concentration.