Molecular Devices ImageXpress Micro 4 High Content Imaging System

The Molecular Devices ImageXpress Micro 4 is an advanced high content imaging system designed for quantitative cell-based assays and high-throughput screening in biotechnology, drug discovery, and molecular diagnostics. Featuring a >4 megapixel sCMOS camera and a large 10x field of view (1.97 mm²), the system supports rapid imaging throughput (>200,000 wells/day) critical for bioprocessing and phenotypic profiling workflows.

• Equipped with an air objective range from 1x to 100x and oil immersion objectives at 40x, 60x, and 100x, enabling detailed visualization from whole wells to subcellular features.
• Includes a 5-position filter cube changer supporting up to 5 illumination channels for multiplexed fluorescence imaging, essential in synthetic biology and gene editing assays.
• The system incorporates combined laser and image autofocus to maintain optimal focus across high-density plates, including support for up to 1536-well plates and standard microscope slides, facilitating applications from cell migration assays to neurite outgrowth analysis.
• Compatibility with robotics and environmental controls such as CO2 and temperature regulation supports live-cell imaging necessary for stem cell research, toxicology studies, and infectious disease modeling like COVID-19.
• The integrated Lumencor Sola Light Engine and FC-9 gas mixer enable precise fluorescence excitation and live-cell environment maintenance.
• Widefield imaging and transmitted light modes, including phase contrast and brightfield, increase versatility across diverse experimental requirements.
• The device supports fast scanning protocols, e.g., scanning a 96-well plate with 2 colors and 1 site per well in approximately 2 minutes, optimizing high-throughput imaging pipelines widely adopted in biomedical engineering and molecular biology research.

This ImageXpress Micro 4 system is a critical tool for researchers specializing in biopharmaceutical production pipelines, molecular diagnostics, and live-cell fluorescence analysis, providing customizable modules for various high-throughput and complex image acquisition workflows. It integrates seamlessly into synthetic biology workflows and other biotechnological applications requiring robust phenotypic screening and quantitative imaging. Users will need to obtain the MetaXpress software from Molecular Devices for full image analysis and workflow automation.

This instrument is sold as-is without warranty and without included software but is recommended for laboratories focused on advanced high-content imaging and bioprocessing research needing a reliable, high-speed automated microscope platform.