Molecular Devices CloneSelect Imager FL with DispenCell Single-Cell Dispenser for High-Throughput Cell Line Screening

The Molecular Devices CloneSelect Imager FL with DispenCell Single-Cell Dispenser is a precision laboratory instrument designed for automated high-throughput single-cell imaging and dispensing, critical in monoclonal antibody development, biopharmaceutical cell line generation, and single-cell cloning workflows. This integrated system combines rapid fluorescence and brightfield imaging with precise single-cell dispensing to ensure accurate monoclonality verification and streamline colony screening workflows in molecular diagnostics and bioprocessing applications.

Key technical specifications include:

• Imaging Module (CloneSelect Imager FL):
• High-resolution CMOS camera with selectable resolution modes (1.8 µm high resolution, 3.6 µm standard)
• 4x objective with xenon flash lamp white light transillumination and multichannel fluorescence excitation (GFP/RFP) via Lumencor Aura III LED light engine
• Fast imaging speeds: <2 minutes for 96/384-well plates in brightfield; <8 minutes for fluorescence acquisition
• Compatible with standard 96- and 384-well SBS microplates, handling one plate at a time

• DispenCell Single-Cell Dispenser:
• Low-pressure dispensing (<0.1 psi) minimizing cell stress
• Dual-stage plate capacity (2 plates: 96-well 200 µL and 384-well 50 µL), supporting a 3-tube position loading cart
• No calibration or cleaning required, enabling rapid sample preparation (~10 minutes) and dispensing (5 minutes per 96-well plate)
• Detects key cell parameters including size and doublets for precise single-cell isolation

This compact, integrated system is widely adopted in synthetic biology research, biomanufacturing pipelines, and cell-based assay development, as it reduces manual handling, improves reproducibility, and accelerates clonal cell line establishment. The CloneSelect Imager FL with DispenCell dispenser enhances efficiency in live-cell imaging, fluorescence analysis, and molecular biology workflows by combining high-throughput colony detection with automated single-cell isolation technologies.

Included with the system are software-equipped computers for both the imaging and dispensing modules, user interface peripherals, and all necessary power and communication cables. This instrument is serviced, fully functional, and manufactured in 2023, with warranty and technical support available. It represents an essential solution for laboratories seeking reliable automation in monoclonality assurance and cell line screening within both academic and biopharma industrial settings.