Teledyne ISCO CombiFlash EZ Prep UV/ELSD Preparative Flash Chromatograph System

The Teledyne ISCO CombiFlash EZ Prep UV/ELSD Preparative Flash Chromatograph System is a versatile benchtop platform combining flash purification and preparative HPLC technologies. Designed for efficient compound purification in pharmaceutical research, synthetic biology, and medicinal chemistry workflows, it supports complex separations at preparative scale with precise control over gradients and detection.

• Dual operation modes: switch seamlessly between flash chromatography (max 200 psi) and high-pressure preparative HPLC (up to 3500 psi / 240 bar), optimizing purification workflows.
• Flow rate range: 5–200 mL/min, with ±5% accuracy ensures scalable fractionation from milligram to multi-gram sample quantities.
• Detection: Integrated UV detector operates across 200–400 nm spectrum (±5 nm increments) combined with built-in ELSD for detecting both chromophoric and non-chromophoric compounds—critical for synthetic biology and molecular diagnostics applications.
• Gradient programming: binary gradients among four solvents with programmable linear, step, and isocratic options, maintaining ±3% gradient accuracy for reproducible results in bioprocessing and natural product isolation.
• Precision hardware: dual-head HPLC pumping system, automated self-cleaning flash injection valve, and prep HPLC injection valve with loop enhance injection consistency and sample integrity.
• Temperature control: ELSD drift tube adjustable between 30–90 °C, spray chamber 10–60 °C, carefully regulated to 5 °C below ambient, enabling sensitive aerosol detection during biomanufacturing quality control.
• Size and power: compact footprint at 43 × 43 × 67 cm and 43.6 kg, suitable for standard lab benches; operates on 100–240 VAC, 50/60 Hz power supply.

_Primary applications_ include purification of synthetic organic molecules, isolation of reaction products in medicinal chemistry, separation of complex plant or biological extracts, and preparative-scale cleanup of intermediates in chemical synthesis workflows. The system supports diverse column types, making it essential for biotechnology research and pharmaceutical development pipelines, especially those focusing on gene editing and molecular cloning workflows.

The system undergoes comprehensive service and quality control testing, including verification of power initialization, touchscreen calibration, RFID column and rack detection, flow rate accuracy, gradient performance, and UV/ELSD detector validation using standard caffeine test injections. This ensures reliable operation suitable for high-stakes biopharmaceutical production.

_Supplied accessories_ include solvent intake hoses with filters, waste hoses, column bypass tube, and power cable. Columns, glassware, and racks are sold separately. Custom collection racks and solid load cartridges are available on request.

With built-in dual UV and evaporative light scattering detection, this combi flash chromatograph is widely adopted in synthetic biology research and critical in biopharmaceutical production pipelines where purification precision and detection versatility are paramount. The instrument is backed by technical sales consultation, remote setup and training options, and warranty support, making it a robust choice for research laboratories focused on advanced biotechnology and clinical diagnostics.