Revvity Perkin Elmer Operetta CLS High Content Confocal Imaging Analysis System

The Revvity Perkin Elmer Operetta CLS is an automated high-content confocal imaging system designed for quantitative cell-based assays and live-cell imaging applications critical in molecular diagnostics and biopharmaceutical research. Featuring a confocal optical mode, this platform integrates a laser autofocus system (785 ±10 nm, 12 mW Class 3B) with 8 distinct LED excitation sources spanning 355 to 675 nm to enable multiplexed fluorescence imaging widely adopted in synthetic biology and phenotypic profiling workflows.

Key technical features include:

• High-sensitivity 4.7 MP sCMOS camera for low-noise, high-resolution image acquisition essential in biotechnology and cell imaging.
• Environmental control module capable of precise temperature regulation (37–42°C ±1°C) and CO2 control (1–10% ±0.5%) to maintain physiological conditions during live-cell experiments.
• Water immersion capability (optional objectives) for enhanced optical performance in live-cell and 3D tissue imaging.
• Multiple emission bandpass filters (430–500 nm, 570–650 nm, 655–760 nm) allow efficient spectral separation for complex multi-channel fluorescence assays.
• Compatible with multiwell plate formats (96–384 well) and optical-bottom slides, facilitating high-throughput screening in drug discovery and molecular cloning workflows.

This system supports robust image acquisition in drug toxicity studies, phenotypic profiling, and longitudinal live-cell assays, making it critical in bioprocessing and biomedical engineering research pipelines. The instrument is fully tested for optical path clarity, laser safety interlocks, filter wheel operation, and XYZ stage precision by an experienced service team, ensuring reliable performance. Licensed with Harmony software and including a monitor, keyboard, and communication cables, the Operetta CLS is optimized for flexibility in fluorescence analysis and high-content screening used by clinical diagnostic labs and biotechnology researchers alike.

Purchasing this pre-owned system offers a cost-effective solution to advance synthetic biology and molecular diagnostics projects, backed by a warranty and technical support. It is widely used in biopharmaceutical production pipelines requiring reproducible automated imaging under live-cell conditions.