10-Column DNA/RNA Synthesizer for Automated Oligonucleotide Synthesis

The 10-Column DNA Synthesizer is an automated instrument designed for simultaneous synthesis of up to 10 oligonucleotides in a single run, optimizing throughput for molecular biology and synthetic biology workflows. Key features include:

• Minimal reagent consumption due to the patented Slider Block technology with low dead volume (~3 µl), allowing:
• Fast program solvent use as low as 0.6 ml per coupling
• High-quality program solvent use of 1.1 ml per coupling
• Multi-scale synthesis capability ranging from 10 nmole to 5 µmole per column with optional separate slider for higher yields
• Efficient synthesis speed:
• 10 coupling cycles completed in 6 minutes
• 20-unit Poly-T synthesis completed in 1 hour 45 minutes (fast program), or up to 2 hours 55 minutes (high-quality program)
• Integrated reaction vessels eliminate the need for costly, pre-packed columns—CPG materials are fed directly into the Slider Block system
• Maintenance-free operation with no valve replacement required, reducing downtime and ongoing servicing costs
• Real-time process monitoring with a DMT system that measures each column's coupling efficiency via absorption, providing warning signals or automatic process halting if thresholds are not met
• Flexible software integration, supporting direct data transfer from PC databases and compatibility with various software suites, enhancing workflow automation and data management

This synthesizer is essential for *biotechnology research*, molecular diagnostics, gene editing projects, and synthetic biology applications where reliable, high-throughput oligonucleotide synthesis is critical. Its low reagent consumption and user-oriented design make it well suited for *bioprocessing* and *biomanufacturing* pipelines requiring consistent, scalable DNA/RNA synthesis.