Bruker AVANCE

The Bruker AV series of nuclear magnetic resonance (NMR) spectrometers are designed to deliver high-resolution molecular structure analysis, making them indispensable tools in various scientific disciplines. These instruments are particularly valuable in biotechnology, where precise molecular characterisation is crucial.

Key features include:

• High Sensitivity and Resolution: Enables detailed analysis of complex biomolecules, essential for applications such as protein structure determination and drug discovery.

• Versatile Probe Options: Accommodates a range of probes, including triple resonance cryoprobes, facilitating diverse experimental setups.

• Automated Sample Handling: Equipped with autosamplers like the SampleXpress, enhancing throughput and efficiency in high-volume laboratories.

• Variable Temperature Control: Supports experiments across a broad temperature range, accommodating studies of temperature-sensitive biomolecular interactions.

The Bruker AV series is widely utilised in fields such as molecular biology, biochemistry, and pharmaceutical research. Its applications are particularly prominent in biotechnology, where NMR spectroscopy plays a pivotal role in bioprocessing, molecular diagnostics, and biomanufacturing. For instance, NMR has been instrumental in accelerating antiviral drug discovery programmes, contributing to the development of treatments for diseases like HCV, HIV, and SARS-CoV-2.

Commonly found in university laboratories, biomedical research centres, and pharmaceutical companies, the Bruker AV series has been a cornerstone in NMR spectroscopy since its introduction. Its enduring relevance is evidenced by installations such as the Bruker Avance III HD 500 MHz spectrometer at the University of Minnesota, which has been operational since 2011.

Bruker's commitment to innovation ensures that the AV series continues to meet the evolving demands of the scientific community, solidifying its position as a trusted solution for advanced molecular analysis.