Repligen 908Devices REBEL Cell Culture Analyzer Unit 2 with Integrated CE-ESI-HPMS for Cell Culture Media Analysis

The Repligen 908Devices REBEL Cell Culture Analyzer Unit 2 is a benchtop analytical instrument designed for rapid, at-line quantification of critical components in cell culture media. This advanced system integrates capillary electrophoresis (CE) with electrospray ionization high-performance mass spectrometry (ESI-HPMS), enabling precise measurement of up to 33 analytes—including 22 amino acids, 6 biogenic amines, and 5 vitamins—essential for biotechnology and molecular diagnostics applications.

Key technical features include:

• Integrated CE-ESI-HPMS detection system delivering high sensitivity and selectivity for complex media matrices.
• Capability to process vial trays and 96-well plates, supporting medium-throughput workflows in bioprocess development and synthetic biology research.
• Use of single-use REBEL chips rated for up to 200 runs (consumables not included), minimizing cross-sample contamination risks.
• Typical sample run time of approximately 15 minutes, optimizing turnaround for upstream bioprocess monitoring and cell culture nutrient tracking.
• Automated calibration and system verification ensure reproducible and reliable quantitative analysis critical in gene editing and biomanufacturing pipelines.
• Compact design (22" H × 13" W × 27" D, 83 lb) compatible with standard laboratory power (100–240 VAC, 50–60 Hz, 350 W), making it suitable for space-limited research environments.

This analyzer is widely adopted in biotechnology fields for monitoring nutrient consumption, optimizing feeding strategies, and tracking metabolite dynamics during live-cell imaging and biopharmaceutical production. Its rapid, at-line analysis capability eliminates delays associated with off-site testing, facilitating real-time decision-making in molecular cloning workflows and synthetic biology experimentation.

The REBEL system comes fully tested and calibrated, with low usage history (Chip Insert Count = 61, Sample Count = 272), supporting reliable performance in clinical diagnostics and biomedical engineering laboratories. Remote and on-site installation, training, and technical support are available, enhancing integration into existing bioprocessing setups.

Primary keywords: cell culture analyzer, CE-ESI-MS, bioprocess monitoring, amino acid analysis, cell media quantification Long-tail phrases: at-line analysis of cell culture media, essential for molecular cloning workflows, widely adopted in synthetic biology research, critical in biopharmaceutical production pipelines, fast turnover in bioprocess development, compact benchtop CE-MS analyzer for biotechnology.