TangenX equipment

About TangenX

TangenX is an American manufacturer of tangential flow filtration membranes and cassettes, founded in 2004 to supply ultrafiltration and microfiltration products to biopharma, biotech, and life sciences customers from lab to process scale. The company is headquartered in Shrewsbury, Massachusetts. Since December 2016 it has been part of Repligen Corporation, which acquired it that year. Its core products are tangential flow filtration systems, ultrafiltration and microfiltration membranes, single-use and reusable TFF cassettes, and the hardware and cassette holders that hold them. The named product lines are the Sius single-use cassettes, the Novaset reusable cassettes, the ProStream and HyStream mPES membranes, and the X-Flo membrane screening system. On Questpair, 119 TangenX listings are available from verified suppliers and distributors.

Tangential flow filtration is a membrane separation technique in which the feed stream runs parallel to the membrane surface rather than through it, so the filtration cake does not build up the way it does in dead-end filtration. In biopharmaceutical work this does the concentration and diafiltration steps that sit between cell harvest and final formulation. The Sius and Novaset cassettes handle protein purification and buffer exchange in cell culture harvest streams, and the same membranes are also used for virus filtration and for the clarification stages of biomanufacturing. The mPES membrane chemistry in the ProStream and HyStream lines is a low-binding surface suited to monoclonal antibody and recombinant protein recovery, work that sits inside bioprocessing and downstream processing. The X-Flo screening system lets a development group test membrane cutoffs before scaling, which is where a process for a molecular diagnostics or synthetic biology product gets fixed. These are the long operations a filtration group runs: ultrafiltration membrane concentration of an antibody feed, microfiltration clarification of a harvest, and single-use TFF cassette diafiltration for final buffer exchange.

TangenX TFF product lines on Questpair

The listings group around the brand's own families. The Sius single-use cassettes appear as individual cassettes and in holder-mounted sets, intended for campaigns where a fresh flow path is required per batch. The Novaset reusable cassettes cover the stable-process case, where the membrane is cleaned and regenerated across runs. The ProStream and HyStream mPES membranes are the membrane chemistry underneath both cassette formats, and the X-Flo screening system shows up as development hardware for choosing between them. Alongside the cassettes sit the holders and the broader TFF hardware, which is what turns a cassette into a working filtration station with a feed pump and pressure control. Because the catalogue spans screening gear, consumable cassettes, and the holders that run them, a buyer can assemble a complete tangential flow filtration setup or replace a single component from one source.

What TangenX equipment is listed on Questpair?

Prices range from EUR 86 to EUR 150.656, with an average of EUR 9.689. 99 percent of the listings are used. The inventory is offered by 7 verified suppliers and distributors across 4 countries. For documentation on a specific cassette or system, you can contact Questpair and specialists respond within the hour. Replacement parts can be sourced via Questpair, and a warranty is often possible, arranged in consultation for the specific listing. Because membrane cassettes are consumables with a finite service life, the remaining capacity of a used item is best confirmed against the individual listing rather than assumed from the product line alone.

Questpair review of TangenX

Our take based on listings data and supplier feedback

TangenX occupies a narrow but demanding part of the laboratory equipment market: tangential flow filtration for biopharmaceutical processing. The listings on Questpair reflect that specialisation, and three features stand out when reading the catalogue against what the brand actually makes.

The first is the depth of used inventory. Of the 119 items listed, 99 percent of the listings are used. For a buyer working in bioprocessing, that matters because membrane filtration hardware at process scale is normally bought new through extended lead times. A pool of used cassettes, holders, and skids gives a development group a way to equip a protein purification or buffer exchange step without waiting on a new build. The single-use Sius line and the reusable Novaset line both appear, which is useful because the two serve different operating economies: single-use suits a campaign where cross-contamination control dominates, reusable suits a stable process where cassette regeneration lowers the running cost per batch.

The second feature is price range. Prices run from EUR 86 to EUR 150.656. That spread is wide because the catalogue mixes consumable-grade items with capital hardware. At the low end sit individual cassettes and membrane components; at the high end sit complete TFF systems with holders, pumps, and control. The average, at EUR 9.689, sits well below the ceiling, which tells you the bulk of the listings are components and mid-size assemblies rather than full process skids. A buyer scoping a concentration or diafiltration step can therefore find both a single replacement cassette and a complete system in the same catalogue, and can size the purchase to the stage of work rather than to a fixed product tier.

The third feature is the presence of the X-Flo membrane screening system alongside the production formats. Screening hardware is what a process development group uses to choose a membrane chemistry and cutoff before committing to a scale-up. Having it listed next to the ProStream and HyStream mPES membranes means the catalogue supports the early screening work and the later production work from one source, which shortens the path from a bench trial to a defined process. This is relevant to molecular biology and biomanufacturing groups that run ultrafiltration and microfiltration as part of harvest clarification, concentration, and final formulation.

Two limits are worth stating plainly. The catalogue distinguishes new from used and nothing finer, so condition beyond that is a matter for the individual listing. And membrane products are consumables with a service life, so a used cassette's remaining capacity is something to confirm per item rather than to assume. Within those bounds, the TangenX listings give a filtration group a realistic route to both screening and production hardware across 4 countries and 7 verified suppliers and distributors.

**Deep used inventory at process scale**

Of the 119 TangenX listings, 118 are used, giving buyers access to ultrafiltration and microfiltration hardware that is otherwise sold through long OEM lead times.

**Wide price span from cassettes to full systems**

Prices run from EUR 86 to EUR 150.656, covering individual single-use cassettes at the low end and complete TFF skids with holders at the high end.

**Membrane screening and both cassette formats represented**

Listings span the Sius single-use line, the Novaset reusable format, and the X-Flo screening system, so a buyer can match a listing to an existing development or production workflow.