Nova Biomedical BioProfile FLEX2 Automated Cell Culture Analyzer with OSM48 Osmometer and Multi-Module Testing Suite

The Nova Biomedical BioProfile FLEX2 Automated Cell Culture Analyzer is a sophisticated multi-module analytical platform designed for comprehensive cell culture and bioprocess monitoring in biotechnology and molecular diagnostics. This system integrates the following modules:

• Chemistry Module: Performs 11 analyte tests including glucose (Gluc), lactate (Lac), glutamine (Gln), glutamate (Glu), ammonium (NH4+), sodium (Na+), potassium (K+), and calcium (Ca++) using maintenance-free single-use microsensor cards, enabling minimal calibration and upkeep.
• Gas Module: Measures pH, partial pressure of carbon dioxide (PCO2), and partial pressure of oxygen (PO2) with rapid analysis time to support real-time metabolic assessments.
• OSM48 Osmometer Module: Provides high-throughput osmolality measurements essential for monitoring cell culture media and bioreactor conditions.
• Cell Density and Viability Module: Capable of analyzing cell diameters from 4 to 70 µm and cell densities ranging from 100,000 to 80,000,000 cells/mL, critical in evaluating cell health and growth kinetics.

Key technical features include automated sampling compatibility with 96-well plates, syringes, and a 24-position “load-and-go” external tray, facilitating efficient workflow integration for bioprocessing and synthetic biology research. The analyzer delivers results in approximately 4.5 minutes when running all modules concurrently using as little as 275 µL sample volume, supporting rapid process development and media optimization.

Physical specs include a footprint of 43 x 64 x 61 cm and a weight of 42.6 kg (94 lb), suitable for benchtop laboratory environments. The system supports cartridge-based reagent management, eliminating frequent reagent handling and enhancing reproducibility.

Applications encompass monitoring nutrient consumption, metabolite production, cell viability, and osmolality during mammalian cell culture, essential for upstream biomanufacturing process control and molecular cloning workflows. This analyzer is widely adopted in biopharmaceutical production pipelines for routine quality control and scale-up studies.

Technicians verify instrument functionality through extensive testing of mechanical, optical, and fluidic components, ensuring reliability, reproducibility, and compliance with industrial standards.

By incorporating this automated cell culture analyzer, labs can enhance throughput and data quality in live-cell imaging, fluorescence analysis, and bioprocess monitoring workflows critical in cutting-edge biotechnology and biomedical engineering research.