Nova Biomedical BioProfile FLEX2 Automated Cell Culture Analyzer with OSM48 Osmometer and Multiparameter Modules

The Nova Biomedical BioProfile FLEX2 Automated Cell Culture Analyzer is an advanced multiparameter analyzer designed specifically for automated cell culture monitoring in biopharmaceutical environments. This system integrates several critical analytical modules including chemistry, blood gas, osmolality (OSM48 Osmometer), and cell density & viability, supporting comprehensive process control and optimization within biotechnology workflows such as bioprocessing, molecular diagnostics, and synthetic biology research.

Key technical features include:

• Modular design: Chemistry, Gas, Osmolality, and Cell Density/Viability modules combined to deliver extensive metabolite and physiological profiling.
• Assay capability: Measures glucose, lactate, glutamine, glutamate, ammonia, sodium, potassium, calcium, pH, PCO2, PO2, osmolality, and cell characteristics.
• Sample formats: Automated sampling from 96-well plates, syringes, or external 24-position trays enabling compatibility with bioreactors and multiwell plate workflows.
• Low sample volume & rapid analysis: Individual module analysis times from 120 to 240 seconds with minimal sample volume (135–275 µL), facilitating high-throughput cell culture analytics.
• Maintenance-free sensor card technology: Disposable microsensor cards simplify reagent management, eliminate frequent calibrations, and reduce downtime.
• Cell density and viability module: Measures cell diameter (4–70 µm) and density (100,000 to 80,000,000 cells/mL), critical for tracking cell health during scale-up and biomanufacturing processes.
• Compact footprint: Dimensions 43 x 64 x 61 cm; weight 42.6 kg, suitable for integration within laboratory benchtop environments.

Applications of the BioProfile FLEX2 include:

• Real-time monitoring of nutrient consumption and metabolite production during cell culture in biopharmaceutical production pipelines.
• Quality control and in-process sampling for upstream bioprocess optimization and troubleshooting.
• Comparative analysis of cell line performance and media formulation adjustments in molecular biology and synthetic biology research.
• Live-cell culture monitoring to maintain process consistency and control, supporting regulatory compliance in clinical diagnostics and biomanufacturing.

This analyzer’s comprehensive data acquisition supports essential biotechnology workflows such as gene editing, molecular cloning, and scale-up studies, making it a critical tool for researchers and production scientists involved in industrial cell culture applications and bioprocess engineering.

Overall, the Nova Biomedical BioProfile FLEX2 offers a reliable, automated solution for simultaneous multi-analyte testing that enhances throughput and data accuracy in complex cell culture and bioprocess monitoring environments.