Nova Biomedical BioProfile FLEX2 Automated Cell Culture Analyzer with OSM48 Osmometer and Gas Module

The Nova Biomedical BioProfile FLEX2 Automated Cell Culture Analyzer is a highly specialized instrument designed for comprehensive metabolic monitoring in biotechnology, cell culture, and bioprocessing applications. It integrates three analytical modules—chemistry, gas, and osmolality—to provide automated, rapid measurement of critical cell culture parameters essential for process development, molecular diagnostics, and biopharmaceutical manufacturing.

Key features include:

• Modular configuration: Chemistry, Gas, and OSM48 Osmometer modules provide simultaneous or individual testing.
• Multiparametric analysis: Measures glucose, lactate, glutamine, glutamate, ammonium, electrolytes (Na+, K+, Ca2+), pH, PCO2, PO2, and osmolality, essential for monitoring nutrient consumption, metabolite accumulation, and cell viability.
• Maintenance-free single-use microsensor cards: Reduce maintenance and eliminate frequent calibration, improving reliability and uptime in demanding laboratory workflows.
• Automated sample handling: Compatible with 96-well plates, syringes, and a 24-position external load-and-go tray to streamline high-throughput bioprocess monitoring and live-cell culture analysis.
• Low sample volumes and rapid turnaround: Individual module analysis times range from 120 to 240 seconds with sample volumes between 135-275 µL; combined operation completes within 270 seconds using minimal volume (275 µL), supporting efficient use of precious biological samples.
• Robust design: Dimensions of 43 x 64 x 61 cm and weight of 42.6 kg enable stable benchtop installation in biotechnology and clinical diagnostic labs.

Applications are diverse and critical to the biomanufacturing pipeline, including:

• In-process monitoring of nutrient utilization and metabolite profiles during upstream cell culture
• Quality control of bioreactor samples in synthetic biology and molecular cloning workflows
• Media optimization and feeding strategy development for enhanced cell line performance
• Tracking osmotic balance and cell viability parameters to ensure process consistency and product quality
• Scale-up and troubleshooting during biological drug production and molecular diagnostics

The analyzer’s cartridge-based reagent management system (RMS) facilitates walk-away operation for up to 24 samples, making it a valuable asset for laboratories focusing on biomedical engineering and cell imaging research that require precise environmental control and metabolic profiling.

This instrument supports advanced research fields such as molecular biology, neuroscience cell metabolism studies, and clinical diagnostics where rapid, accurate, and multiplexed analysis of cell culture environments is essential.

Overall, the Nova Biomedical BioProfile FLEX2 is a robust, versatile, and user-friendly platform designed to support high-throughput, automated metabolic assays critical to biotechnology research, bioprocess development, and molecular diagnostics workflows.