Hiden Analytical QIC BioStream-C Bench Top Gas Analyser with Proteus Multistream Valve and HAL 201 Mass Spectrometer

The Hiden Analytical QIC BioStream-C Bench Top Gas Analyser is engineered for precise, real-time analysis of fermentation off-gas in large-scale bioreactors or fermentors commonly used in bioprocessing and molecular diagnostics workflows. It integrates a HAL 201 or HAL 201 RC quadrupole mass spectrometer, optimized for residual gas analysis and multi-species detection, ensuring stable and accurate gas composition measurement at parts-per-billion (PPB) sensitivity.

Key technical features include:

• Top-mounted Proteus multistream valve capable of handling 40 discrete gas sample streams, enabling rapid stream switching in under 0.6 seconds to support complex synthetic biology and biomanufacturing processes.
• Dual mass flow meters capable of precise sample flow control at rates up to 12 L/min, facilitating accurate calculation of O₂ Uptake Rate (OUR) and CO₂ Evolution Rate (CER) critical in metabolic activity monitoring during aerobic and anaerobic fermentations.
• Design considerations such as zero crosstalk and minimal memory effects between samples ensure reliable data integrity across multiple gas streams during extended bioprocess monitoring.
• Flow paths and sample tubing are engineered to minimize condensation and maintain measurement reliability, which is essential in biotechnology applications involving volatile or humid off-gas mixtures.
• The analyser supports both high-flow and low-flow configurations, allowing flexibility for diverse gas analysis scenarios in clinical diagnostics, biochemical engineering, and biotechnology.

This system includes a Proteus Valve Drive Module and an Edwards nXDS6i dry scroll pump for superior vacuum generation and system stability, supporting consistent mass spectrometry performance.

Widely adopted in synthetic biology research and biopharmaceutical production pipelines, the QIC BioStream-C provides critical data for optimizing fermentation conditions, bioprocess control, and metabolic flux analysis. It is a compact, bench-top unit designed for space-efficient deployment in laboratory and pilot-scale bioprocessing facilities.

This analyser is sold without software and is offered "as is"; full operational testing requires compatible software provision. It is suitable for specialized research institutions and companies engaged in gene editing, biomanufacturing, and industrial biotechnology, requiring detailed multi-gas analysis with stringent performance criteria.

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