Particle Works ALiS Automated Library Synthesis System for High-Throughput Nanoparticle and mRNA Screening

The Particle Works ALiS Automated Library Synthesis System is a microfluidics-based platform designed for high-throughput synthesis and screening of nanoparticle formulations, including mRNA lipid nanoparticles (mRNA-LNPs). This advanced system facilitates early-stage drug development by enabling up to 96 unique experiments per working day with as little as 100 µl reagent volume per experiment, optimizing precious material usage critical in bioprocessing and molecular diagnostics workflows.

Key technical features include:

• Full walk-away automation of complex nanoparticle synthesis and screening protocols, allowing enhanced operational efficiency in busy laboratory environments.
• Integration of precision-engineered reusable microfluidic chips with proprietary Anti-dispersion Technology for controlled fluid convergence, ensuring uniform nanoparticle formulation and reaction reproducibility.
• Flexibility to vary both formulations (e.g., lipid ratios and reagent concentrations) and process parameters (e.g., total flow rate, flow rate ratios) on a per-well basis within covered 96-well plates.
• Capability to aspirate from and dispense into standard 96-well formats, making it widely compatible with existing laboratory automation systems and liquid handling workflows.

The ALiS system is essential for molecular cloning workflows, widely adopted in synthetic biology research, and critical in biopharmaceutical production pipelines focused on nanoparticle-based drug delivery systems. It accelerates lead candidate discovery by enabling rapid exploration of vast formulation parameter space, supporting research areas such as biotechnology, gene editing, and nanomedicine. This makes the ALiS system a vital instrument for laboratories specializing in live-cell imaging, fluorescence analysis, and biomedical engineering applications that require precise nanoparticle synthesis and high-throughput screening capabilities.