Nova Biomedical BioProfile FLEX2 Automated Cell Culture Analyzer with OSM48 Osmometer and Multiparameter Modules

The Nova Biomedical BioProfile FLEX2 Automated Cell Culture Analyzer integrates multiple analytical functions, combining chemistry, blood gas, osmolality, and cell density/viability assessments within a single platform optimized for biotechnology and bioprocessing environments. It is widely adopted in molecular diagnostics, biopharmaceutical production pipelines, and synthetic biology research for real-time monitoring of cell culture health and process parameters.

Key technical features include:

• Modular Configuration: Chemistry, Gas, Osmolality (OSM48 Osmometer), and Cell Density/Viability modules for comprehensive sample profiling.
• Maintenance-Free Sensor Cards: Utilizes single-use microsensor cards enabling 11 distinct chemistry tests (Glucose, Lactate, Glutamine, Glutamate, Ammonium, Sodium, Potassium, Calcium) with minimal calibration and upkeep.
• Automated Sampling: Supports automated sampling from 96-well plates, syringes, and a 24-position external “load-and-go” sample tray, facilitating walk-away operation and high-throughput workflows.
• Rapid Analysis: Individual module analysis times range from 120 to 240 seconds with low sample volume requirements (120-275 µL), enabling timely bioprocess monitoring and metabolic profiling critical in cell culture optimization.
• Cell Density & Viability Measurement: Measures cell diameter (4–70 µm) and density (100,000 to 80,000,000 cells/mL), essential for monitoring cell health during gene editing and biomanufacturing processes.
• Compact Footprint: Dimensions of 43 x 64 x 61 cm and weight of 42.6 kg allow convenient placement in bioprocessing laboratories and clinical diagnostic settings.

Applications include:

• Real-time nutrient consumption and metabolite production monitoring during cell culture and fermentation processes.
• Quality control of bioreactor samples throughout upstream bioprocess development and scale-up studies.
• Tracking critical cell health parameters such as viability and osmolality in molecular cloning and synthetic biology workflows.
• Optimization of media formulations and feeding strategies in biotechnology research.
• Supporting in-process monitoring and troubleshooting in biopharmaceutical manufacturing pipelines to ensure process control and consistency.

This analyzer’s cartridge-based reagent management system (RMS) and maintenance-free sensors reduce downtime and support high data reproducibility, making it indispensable for researchers specializing in cell imaging, fluorescence analysis, and live-cell monitoring within biomedical engineering and biotechnology sectors.

Overall, the BioProfile FLEX2 is a robust, versatile solution facilitating comprehensive biochemical and cellular analysis critical to molecular diagnostics, bioprocess monitoring, and synthetic biology applications.