Bruker Berkeley Lights Beacon CAS 2.4 Premium Optofluidic Single-Cell Analysis System with Multi-Chip Fluidics Station

The Bruker Berkeley Lights Beacon CAS 2.4 Premium is a sophisticated optofluidic single-cell analysis system designed for high-throughput biotechnology applications including monoclonal antibody discovery, cell line development (CLD), and functional genomics. It combines advanced optics, semiconductor imaging technology, and precision nanofluidics to enable automated isolation, manipulation, and functional screening of individual cells.

Key Technical Features:

• OptoElectro Positioning Technology: Light-driven, non-contact single-cell positioning into NanoPen chambers (500 pL or 1 nL volume) enabling precise cell handling without mechanical stress.
• Integrated Fluorescence and Brightfield Imaging: Utilizes Nikon Plan Fluor 10x/0.30 DIC-capable and 4x/0.28 objectives, Andor Zyla 4.2 USB3 sCMOS camera, and X-Cite 120LED fluorescence illumination with 5 filter cubes for multiplexed imaging assays.
• Multi-Assay Workflow Capability: Supports sequential or simultaneous assays measuring cell secretion, binding, proliferation, and viability critical for molecular diagnostics and synthetic biology research.
• Environmental Control: Per-chip temperature regulation (10°C to 40°C) with Ibidi CO₂/O₂ gas mixer controller for physiological cell culture conditions essential in bioprocessing and cell therapy.
• Integrated Fluidics Station: Multi-channel syringe pump control, reagent reservoirs, gas-assisted microfluidic control, and chip docking with precision tilt alignment for robust media, reagent, and waste handling.
• Data Export and Software: Cell Analysis Suite (CAS) v2.4 Premium for data acquisition, real-time image and functional analysis, and export of selected single cells for downstream expansion or biomanufacturing pipelines.

This system is widely adopted by biotechnology researchers for cell line development, immune profiling, and functional genomics workflows, offering non-contact single-cell manipulation crucial in gene editing and molecular cloning. The modular multi-chip fluidics station enhances throughput by enabling parallel processing of OptoSelect chips with up to 11,000 NanoPen chambers.

Dimensions & Power:

• Footprint: 46 in (W) × 34 in (D) × 71.5 in (H)
• Weight: ~1,260 lb
• Power: 110–240 V AC, 50–60 Hz

The Bruker Berkeley Lights Beacon platform provides a critical solution for researchers in biotechnology and biomedical engineering seeking automated live-cell imaging, fluorescence analysis, and high-content screening to accelerate biopharmaceutical production pipelines and synthetic biology research projects.