Bruker Berkeley Lights Beacon CAS 2.4 Premium Optofluidic Single-Cell Analysis System

The Bruker Berkeley Lights Beacon CAS 2.4 Premium is a sophisticated optofluidic system designed for automated, high-precision single-cell analysis in biotechnology and cell biology research. This integrated platform combines semiconductor optics, nanofluidics, and advanced fluorescence imaging to enable real-time manipulation, phenotyping, and live-cell monitoring critical for molecular diagnostics and bioprocessing workflows.

Key technical specifications include:

• Optofluidic single-cell manipulation: Utilizes DLP-based Optoelectronic Positioning (OEP) technology to precisely direct cells into NanoPen chambers (500 pL to 1 nL volumes).
• Microfluidic system: Multi-channel fluidics with reagent reservoirs, chip docking assembly, and integrated gas mixer controller supporting CO₂/O₂ supply for live-cell environmental control.
• Fluorescence imaging module: Equipped with Nikon Plan Fluor objectives (10x/0.30 DIC capable, 4x/0.28) and a high-sensitivity Andor Zyla sCMOS camera for detailed fluorescence and brightfield imaging.
• Temperature control: Per-chip thermal regulation ranging from 10°C to 40°C for precise culture conditions.
• Software suite: Cell Analysis Suite (CAS) version 2.4 Premium and Assay Analyzer 2.4 support sequential or simultaneous multi-assay workflows including antibody discovery, clone selection, and functional immune cell profiling.
• Environmental gas control: Ibidi CO₂/O₂ gas mixer enables in situ live-cell culture environment critical for biomanufacturing and biomedical applications.

The system dimensions are approximately 46" W × 34" D × 71.5" H, with a weight of ~1260 lb, supporting a robust platform for biotechnology labs focused on single-cell secretion assays, phenotype-to-genotype studies, and synthetic biology research workflows.

This advanced platform is widely adopted in synthetic biology and molecular cloning workflows, essential for biopharmaceutical development pipelines and biomedical engineering applications. Its live-cell export capability facilitates downstream molecular diagnostics and cell-based assay integration.

Primary keywords such as "single-cell analysis system," "optofluidic platform," "fluorescence imaging," and "microfluidic cell manipulation" are emphasized while incorporating long-tail biotechnology phrases like "critical in biopharmaceutical production pipelines" and "essential for molecular cloning workflows."

Please note this unit is sold as-is with no warranty due to the lack of consumables for full functional testing. Consumables such as the T Cell Profiling Kit, Cell Line Development Kit, and Antibody Discovery Kit are required for assay operation. The system supports US and international shipping with detailed packing compliant to ISPM15 standards.

Applications:

• Single-cell antibody discovery and screening
• Cell line development and clone selection
• Functional immune cell profiling
• Single-cell secretion and binding assays
• Phenotype-to-genotype correlation studies

This Bruker Berkeley Lights Beacon system delivers precision and versatility for researchers engaged in advanced biotechnology fields including gene editing, synthetic biology, and live-cell fluorescence analysis.