Advanced Instruments Solentim Cell Metric VIPS Automated Single-Cell Seeding and Imaging System

The Advanced Instruments Solentim Cell Metric VIPS System is an automated benchtop device designed for precise single-cell dispensing and high-resolution imaging in 96-well plates, critical in *biotechnology*, *cell therapy*, and *molecular diagnostics*. Utilizing a patented microfluidic seeding mechanism, it gently places living cells via low-pressure nanoliter droplets (<1 psi), suitable for fragile cell lines such as *iPSCs*, *CHO*, and *HEK293*.

Key technical features include:

• Single-cell dispensing verified immediately through two-step clonality assurance, ensuring monoclonality essential for regulatory submission and *bioprocessing* quality control.
• Z-stack in-well imaging at 20 focal depths delivers superior depth resolution and clear visualization of seeded cells even at well edges, supported by whole-plate laser focus scanning to compensate for plate variations.
• Integrated automated media dispensing following seeding optimizes cell viability and growth conditions.
• A built-in automated Wash Station performs cleaning and sterilization protocols to minimize cross-contamination risk across successive experiments, vital in *synthetic biology* and *biopharmaceutical production pipelines*.
• The system runs on dedicated hardware with Cell Metrics software (VIPS V1.0 and Cell Metrics V3.16), featuring GPU-accelerated image processing, fluorescent imaging analysis, barcode reading, and clonality verification modules tailored for *live-cell imaging* and *clonal cell line development*.

Applications span:

• Clonal cell line development workflows,
• Single-cell isolation with immediate in-situ imaging,
• Monoclonality assurance supporting *gene editing* and *molecular cloning* workflows,
• Screening for antibody-producing cells in *molecular biology* and *biotechnology* research.

This system is widely adopted by universities, biopharma companies, and clinical diagnostics labs seeking precise and reproducible cell line generation critical for *biomanufacturing* and *molecular diagnostics* assays. The compact footprint and user-friendly interface allow seamless integration into existing laboratory automation environments supporting high-throughput *cell imaging* and *fluorescence analysis*.

Comes serviced, fully functional with warranty, and includes:

• Cell Metric VIPS Single Cell Seeding System,
• Wash Station,
• Dual 24V power supplies,
• Computer preloaded with proprietary imaging and verification software,
• All necessary power and communication cables.

Consumables such as the proprietary cell reservoir are not included and must be purchased from the manufacturer to maintain system integrity and performance. The vendor offers technical consultation, onsite installation options (Boston area), and full after-sales support, ensuring system readiness for complex *biotechnology* research workflows.

This equipment is essential for researchers focused on *cell therapy development*, *bioprocessing quality assurance*, and *synthetic biology applications* requiring robust clonality verification and high-throughput single-cell manipulation.