Axon Axopatch 200B Patch Clamp Electrophysiology System with CV 203BU Headstage, Digidata 1440A and pCLAMP 10

The Axon Axopatch 200B patch clamp electrophysiology system is configured for low-noise, high-precision whole-cell and single-channel recordings. The package combines an Axopatch 200B microelectrode amplifier, CV 203BU headstage, Axon Digidata 1440A digitizer, data acquisition computer and pCLAMP 10 software.

Included configuration

• Axopatch 200B amplifier main unit
• One CV 203BU single-channel headstage
• Axon Digidata 1440A A/D and D/A digitizer
• USB 2.0 cable, headstage connection cable, power cables and signal connectors
• Data acquisition PC with pCLAMP 10 license dongle
• pCLAMP software with Clampex data acquisition and Clampfit data analysis modules
• Pre-installed Axopatch and Digidata drivers

Axopatch 200B amplifier

• Low-noise, high-precision patch clamp amplifier
• High-input-impedance, low-capacitance design
• Supports whole-cell, cell-attached, inside-out and outside-out recording configurations
• Voltage-clamp and current-clamp operating modes
• Integrated capacitive and resistive compensation circuitry
• Built-in low-pass Bessel filter with selectable cutoff frequencies
• Scaled analog outputs for I_Mon, V_Mon and Command signals
• Compatible with standard pipette holders through the CV 203BU headstage

Digidata 1440A digitizer

• USB 2.0 computer interface
• Sampling rate up to 250 kHz per channel
• 16-bit analog-to-digital conversion
• 8 analog input channels
• 4 analog output channels
• 8 digital output lines
• 8 digital input lines

The digitizer provides high-speed signal acquisition and command-signal delivery for voltage-clamp experiments, supporting accurate membrane-current recording and real-time experimental control.

Software and functionality

• pCLAMP 10 or later, with exact version subject to availability
• Real-time electrophysiology data acquisition and protocol execution
• Automated pulse generation, seal testing and leak subtraction
• Customizable stimulation templates and data visualization
• Event detection, filtering and post-experiment analysis through Clampfit

This patch clamp recording system is suitable for ion channel characterization, action potential measurement, synaptic physiology, neurotransmitter release studies, pharmacology assays, membrane biophysics and cell excitability research. It is also applicable to biotechnology workflows involving cellular electrophysiology, drug discovery and molecular pharmacology.

Optional accessories available separately may include additional pipette holders, extra headstages, vibration isolation tables, Faraday cages, patch clamp micromanipulators, perfusion systems and stimulus isolators.