Terumo Quantum Flex Automated Hollow-Fiber Cell Expansion System

The Terumo Quantum Flex Cell Expansion System is an advanced, automated hollow-fiber bioreactor platform designed for scalable expansion of suspension and adherent cells under controlled, low-shear conditions. Featuring a closed hollow-fiber system with dual intracapillary (IC) and extracapillary (EC) perfusion loops, it enables precise control of cell culture parameters critical for high-yield, viable cell production.

Key technical features include:

• Dual-loop fluidics and hardware with integrated IC and EC circulation and inlet pumps.
• Electronically controlled valves and real-time pressure sensors for IC, EC, wash, and harvest pathways.
• Integrated air removal chamber for improved culture environment stability.
• Temperature-controlled incubation chamber, adjustable between 16–27 °C operating ambient and typically set at 37 °C, maintaining optimal conditions for cell growth.
• Compact footprint measuring 50 × 48.3 × 58.4 cm with a height of 96.5 cm including pole, weighing ≤ 56.7 kg.
• Automated pump and valve management ensuring reproducible fluid dynamics and culture maintenance.
• Barcode scanner integration facilitates traceability and compliance in GMP-regulated bioprocess workflows.

Applications encompass the expansion of T cells, NK cells, stem and progenitor cells, as well as supporting viral vector and exosome production. This system is widely adopted in biotechnology and molecular diagnostics laboratories focusing on cell therapy bioprocessing, gene editing, and synthetic biology research. Its closed-system format reduces manual handling, minimizes contamination risk, and streamlines workflows essential for GMP-compliant biomanufacturing.

The Quantum Flex is engineered to deliver >90% cell viability with harvest volumes under 1 liter, making it critical for biopharmaceutical production pipelines requiring consistent, scalable, and high-quality cell yields. Its application in live-cell imaging studies and fluorescence analysis for cellular quality control further supports advanced research needs.

This system is accompanied by comprehensive technical validation, including temperature control, fluidics integrity, and sensor accuracy testing, ensuring reliable operation post-shipment. Consumables such as disposable expansion sets, sterile harvest bags, and media/reagent bags are required but not included.

Ideal for research professionals and laboratory managers in academic institutions and biopharma companies aiming to optimize automated cell culture processes in regenerative medicine, immunotherapy, and synthetic biology domains.