Malvern Creoptix WAVEdelta GCI Label-Free Biomolecular Interaction Analysis System with WAVEsampler Autosampler

The Malvern Creoptix WAVEdelta is a high-sensitivity Grating-Coupled Interferometry (GCI) biosensor system for real-time, label-free biomolecular interaction and binding analysis. The included WAVEsampler autosampler supports automated sample handling, improved throughput, and reproducible kinetic measurements.

The system is suited to protein–protein interaction studies, small-molecule and fragment screening, antibody characterization, epitope binning, membrane-protein analysis, and biopharmaceutical lead optimization. It can measure weak, transient, and high-affinity interactions without a lower molecular-weight limit.

Included configuration

• Malvern Creoptix WAVEdelta system
• WAVEsampler autosampler
• Two 48-vial racks with 1.5 mL positions
• PC with Creoptix WAVEcontrol V4.9.3
• Tubing and connections
• Power and communication cables
• WAVEchips are consumables and are not included

Performance specifications

• RMS noise: <0.01 pg/mm² at 1 Hz
• Drift: <0.3 pg/mm²/min
• Readout frequency: 1 Hz, 10 Hz, or 40 Hz
• Association constant range:
• Ka = 10²–5 × 10⁷ M⁻¹ s⁻¹ for small molecules
• Ka = 10²–3 × 10⁹ M⁻¹ s⁻¹ for large molecules
• Dissociation constant range: Kd = 10⁻⁶–10 s⁻¹
• Analysis temperature range: 4°C–45°C, maximum 15°C below ambient
• Molecular-weight limit: No lower limit

Fluidics and sample handling

• Four parallel flow channels
• Channel referencing: any combination of the four channels
• Sealed, disposable flow cells integrated into disposable WAVEchips
• Flow rate: 1–400 µL/min
• Compatible with crude samples
• Four-buffer automatic switching
• Injection volume: <450 µL, with 100 µL typical
• Sample storage: ambient or 4°C–20°C
• Sample recovery capability

Data analysis

• Kinetic affinity analysis: ka, kd, KD
• Automated data evaluation
• Predefined kinetic models
• Direct kinetics
• CFCA
• Ligand screening
• waveRAPID

The pre-owned WAVEdelta system was tested for power stability, initialization, PC communication, fluidic priming, chip detection, chip handling, DSMO test-sample operation, and system-test performance. It is appropriate for biotechnology, molecular interaction analysis, drug discovery, antibody development, and biopharmaceutical research workflows.