Advanced Instruments Solentim Cell Metric VIPS Automated Single-Cell Seeding and Imaging System

The Advanced Instruments Solentim Cell Metric VIPS System is an automated platform designed for precise single-cell seeding combined with high-resolution in-well imaging, supporting clonal cell line development workflows widely used in biotechnology and molecular diagnostics. This system integrates microfluidic low-pressure nanoliter droplet dispensing (<1 psi), enabling gentle handling of fragile and high-value cells such as iPSCs, CHO, and HEK293 cells, essential for gene editing and bioprocessing applications.

Key technical specifications and features include:

• Automated single-cell dispensing with patented microfluidic droplet technology ensures consistent monoclonality and reduces cell stress during deposition in 96-well plates.
• In-situ Z-stack imaging with up to 20 focal planes per well provides enhanced depth resolution, facilitating high-clarity cell visualization even at well edges for accurate proliferation and clonality assessment.
• Two-step clonality assurance workflow: immediate verification post-seeding and daily imaging of cell outgrowth, critical for regulatory submissions in biopharmaceutical production pipelines.
• Automated inline media dispensing immediately post-seeding optimizes cell culture conditions with reduced manual intervention.
• Built-in automated wash station offers cleaning and sterilization functionalities to minimize cross-contamination risks and maintain system performance across multiple projects.
• The system includes Cell Metric software suite featuring GPU-accelerated image processing, fluorescent imaging capabilities, barcode reading, clonality reports, and quality control scans, supporting data-rich analysis for synthetic biology and molecular cloning workflows.
• Compact benchtop design integrates easily into existing laboratory environments, enabling streamlined cell line development, antibody screening, and cell therapy research.

Applications commonly served by the Cell Metric VIPS system encompass:

• Clonal cell line development critical in biotechnology and biomanufacturing
• Assurance of monoclonality for cell therapy and molecular diagnostic workflows
• Single-cell isolation and imaging in live-cell and fluorescence analysis
• Screening of antibody-producing cells and high-throughput cell line validation

This system is optimized for users involved in advanced cell imaging, biotechnology research, and clinical bioprocess development requiring precision single-cell handling combined with comprehensive imaging and verification tools. The Cell Metric VIPS supports robust workflows in molecular biology, biopharmaceutical R&D, and synthetic biology, making it essential equipment in contemporary biomedical engineering laboratories.