Waters Quattro Premier XE Tandem Mass Spectrometer with ZSpray Ionisation

The Waters Quattro Premier XE Mass Spectrometer is a tandem triple quadrupole system designed for precise, high-throughput quantitative bioanalysis and screening. Key technical features include:

• Ultra-low carryover ensured by dual wash capability to minimize cross-contamination
• Mass measurements averaged over 5 replicates with standard deviation < 0.05 Da for accuracy
• T-Wave technology providing efficient ion transport, minimized interchannel crosstalk, narrow chromatographic peaks, and increased analysis speed
• Whisper Dynolite photomultiplier detector with near 100% efficiency, neutral noise elimination, rapid polarity switch (20 ms), and maintenance-free vacuum envelope seal
• ZSpray ionisation source coupled with an integrated syringe pump for rapid inject-to-inject cycle times
• Compliance with 21 CFR Part-11 regulations and integration with MassLynx control software
• Applications suitable for quantitative bioanalysis, ADME screening, environmental and food analysis, early candidate profiling, and clinical monitoring of low-dose drugs

Additionally, the system incorporates:

• A rotary vane vacuum pump, 2-stage oil-sealed type
• Nominal pumping speeds: 9.166 × 10⁻³ m³/s at 60 Hz, 7.638 × 10⁻³ m³/s at 50 Hz
• Ultimate pressure achievable: 0.100 Pa

This equipment offers high sensitivity for trace compounds, improved selectivity in complex matrices, and environmental controls for large sample batches, enhancing throughput and analytical precision.