Cytiva ÄKTApurifier 10 & 100 Automated Liquid Chromatography Systems for Bioprocess Scale-Up

The Cytiva ÄKTApurifier 10 and 100 are advanced automated liquid chromatography systems optimized for method development and scalable bioprocess workflows. Equipped with the UNICORN™ control software (v5.10+), these systems enable precise purification from microgram to gram scale, facilitating smooth transitions from laboratory research to biopharmaceutical production.

Key specifications include:

• Flow rates:
• ÄKTApurifier 100 (P-901): up to 100 ml/min at 10 MPa pressure
• ÄKTApurifier 10 (P-903): up to 10 ml/min at 25 MPa pressure
• Detection modules:
• UV-900 Monitor for multiple wavelength UV detection (standard)
• UPC-900 Monitor combining UV absorption with pH and conductivity measurement (included with ÄKTApurifier UPC version)
• Optional accessories: fraction collectors for automated sample collection
• Applications: Widely used in biotechnology for protein purification, molecular diagnostics, synthetic biology research, and bioprocess development. The system supports essential workflows in gene editing validation, biomanufacturing, and molecular cloning.

The integrated platform supports varied chromatography techniques—including affinity, ion exchange, and size exclusion chromatography—making the ÄKTApurifier system critical for high-resolution fractionation in molecular and cellular biology. Its scalable design ensures predictable scale-up from laboratory R&D to clinical and industrial bioprocessing.