Teledyne Isco CombiFlash RF Automated Flash Chromatography System with UV Detection

The Teledyne Isco CombiFlash RF system is a high-performance automated flash chromatography system engineered for rapid and reproducible purification of chemical compounds. Ideal for biotechnology and synthetic biology workflows, this system supports both normal-phase and reversed-phase separations, accommodating complex sample purification required in molecular diagnostics and biopharmaceutical production pipelines.

Key technical features include:

• Isco pump technology ensuring precise solvent delivery and consistent flow rates critical for reproducible separations.
• Binary gradient generation from 2–4 solvent inlets with programmable gradients and automatic solvent selection, enhancing versatility in method development and bioprocessing applications.
• Online UV detection with selectable wavelengths from 200–400 nm (extendable to 780 nm with optional UV-Vis), enabling sensitive monitoring of compounds relevant in cell imaging and fluorescence analysis research fields.
• Optional Evaporative Light Scattering Detector (ELSD) providing additional detection sensitivity for non-UV active compounds, useful in complex biological sample purification.
• Automated fraction collection with high accuracy (± [2 mL + (flow rate ÷ 60)]), critical for isolating purified fractions in gene editing and bioprocessing research.

Technical specifications include:

• Power requirements: 100–240 V, 50/60 Hz; power consumption approx. 200–250 W
• Dimensions (W × D × H): 420 × 360 × 610 mm; weight: 27.6 kg
• Maximum operating pressure up to 1379 kPa (~200 psi), depending on column choice
• Operating environment: 20–40°C with up to 95% relative humidity tolerance during operation

This chromatography platform is widely used in molecular biology laboratories, medicinal chemistry research, and biomanufacturing facilities, supporting high-throughput purification and enhancing reproducibility in biochemical analysis workflows. Its integrated detection and fractionation options make it an essential tool for reliable compound isolation in advanced biotechnological research and clinical diagnostics.