Leica RM2125RT Manual Rotary Microtome for Precise Tissue Sectioning

The Leica RM2125RT Manual Rotary Microtome is a precision instrument designed for routine tissue sectioning in histology, pathology, and biomedical research applications. It enables researchers to produce consistent paraffin-embedded tissue sections with a thickness range from 0.5 to 60 µm, adjustable in fine increments (0–2 µm in 0.5 µm steps, 2–10 µm in 1 µm steps, 10–20 µm in 2 µm steps, and 20–60 µm in 5 µm steps), supporting diverse specimen preparation needs in molecular diagnostics and biotechnology workflows.

Key features include:

• Manual coarse feed control via a wheel for precise specimen advancement
• Mechanical trimming function with selectable thickness from 10 to 50 µm, optimizing initial tissue leveling before fine sectioning
• Specimen retraction mechanism retracting the tissue 220 µm during knife return stroke to protect both blade and sample integrity, essential in sensitive bioprocessing and synthetic biology studies
• A horizontal specimen feed of approximately 28 mm and vertical specimen stroke of 60 mm (±1 mm), facilitating comprehensive sample navigation
• Ergonomic and straightforward layout designed to support repetitive sectioning without unnecessary complexity

This microtome’s compatibility with standard accessories and its robust mechanical design make it widely adopted in clinical diagnostics, biomedical engineering, and research fields requiring high-quality histological sections. It is critical for workflows in gene editing and biomanufacturing, where reliable tissue preparation impacts downstream analysis such as fluorescence microscopy and live-cell imaging.

Dimensions are 19 x 19 x 12 inches, with a weight of 64 lbs, suitable for benchtop laboratory setups. Included components are an adjustable blade holder mount, user manual, and standard warranty coverage.

The Leica RM2125RT is a preferred choice for laboratories demanding precise, consistent microtomy with adaptable section thickness control, optimizing tissue integrity for downstream histopathological and molecular biology analyses.