Molecular Devices CloneSelect Imager FL with DispenCell Integrated Single-Cell Dispenser System

The Molecular Devices CloneSelect Imager FL with DispenCell Single-Cell Dispenser is an advanced, integrated system designed for automated single-cell dispensing and fluorescence/brightfield imaging essential for cell line development and monoclonality verification workflows in biotechnology and molecular diagnostics.

• Imaging System Specifications:
• High-resolution CMOS camera with 1.8 µm (high) and 3.6 µm (standard) resolution
• Imaging speeds: white light imaging (<2 min for 96/384-well plates); fluorescence imaging (<8 min per plate)
• 4× objective lens with Xenon flash lamp for brightfield trans-illumination
• LED-based Lumencor Aura III AURAIII light engine for GFP/RFP multichannel fluorescence
• Compatible with standard 96- and 384-well SBS microplates (single plate capacity)

• DispenCell Single-Cell Dispenser Features:
• Low-pressure dispensing (<0.1 psi) ensuring gentle handling of cells
• Dual plate stage capacity accommodating 2 plates simultaneously with a 3-tube loading cart
• Supports 96-well (200 µL) and 384-well (50 µL) plates
• Designed for minimal cell numbers as low as 100 cells, facilitating accurate single-cell isolation
• No calibration or cleaning required; rapid sample preparation (~10 min) and dispensing (~5 min per 96-well plate)
• Analysis of cell parameters such as size and doublet detection enhances monotoclonality assurance

• Workflow Integration:
• Seamlessly couples high-throughput colony screening with automated single-cell dispensing
• Accelerates monoclonal antibody development and cell line generation critical for biopharmaceutical and synthetic biology research
• Reduces manual handling steps to improve reproducibility in molecular cloning and biomanufacturing pipelines
• Compact hardware design appropriate for streamlined laboratory integration in clinical diagnostics and live-cell imaging setups

• Included Components:
• CloneSelect Imager FL with software and necessary peripherals (computer, monitor, keyboard, mouse)
• DispenCell Single-Cell Dispenser with dedicated software and accessories
• Power and communication cables

This system is widely adopted by researchers in biotechnology and biomedical engineering for efficient single-cell cloning, monoclonality verification, and high-throughput fluorescence analysis. It supports critical steps in molecular diagnostics, synthetic biology research, and bioprocessing applications.

Key advantages include rapid imaging and dispensing, high-precision single-cell isolation, and validated monoclonality verification, making it essential for molecular cloning workflows and biopharmaceutical production pipelines.