Thermo Fisher CTS Rotea Counterflow Centrifugation System for Scalable Cell Processing

The Thermo Fisher CTS Rotea Counterflow Centrifugation System is a compact, closed system designed for gentle, scalable cell processing in research and clinical biomanufacturing. Utilizing counterflow centrifugation, it achieves efficient cell washing, concentration, and separation while minimizing shear stress to maintain high cell viability and recovery, making it essential for molecular diagnostics and cell therapy manufacturing.

Key technical specifications include:

• Centrifugal force: up to 3000 x g
• Peristaltic pump flow rates: 5–110 mL/min (standard kit), 30–160 mL/min (Hi-Flow kit)
• Centrifuge chamber volume: 10 mL
• Cell input range: 5×10^7 to 5×10^9 cells per chamber load
• Output cell concentration: 5×10^6 to 3×10^8 cells/mL
• Recommended input volume: 50 mL to 20 L
• Minimum output volume: 5 mL
• Maximum fluid density: 1.10 g/mL
• Weight: 20 kg (44 lb)

The system supports a wide range of sterile cell processing workflows, including cell separation, enrichment, and buffer exchange, widely adopted in synthetic biology research and bioprocessing of cellular products. Its flexible closed system design ensures contamination-free processing critical in regenerative medicine, gene editing workflows, and biopharmaceutical production pipelines.

Additional highlights:

• Scalable from small-scale research to clinical GMP manufacturing
• Customizable flow rates for delicate cell handling
• Integrated camera for process monitoring
• Automated pinch valves and door lock ensure operational safety and reproducibility
• Compact footprint ideal for laboratory spaces focused on cell imaging and biotechnology applications

The CTS Rotea system is compatible with single-use kits (Standard, Full Flow, Hi-Flow) to maintain sterility and simplify setup. It is extensively tested by experienced service teams to ensure full functionality, including software communication, pump operation, pinch valves, LEDs, and mechanical components.

This system is an integral tool for scientists in cell biology, biomedical engineering, and molecular cloning workflows who require rapid, gentle, and reproducible cell processing solutions. It is critical in biomanufacturing pipelines supporting cell therapy development and clinical diagnostics.

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