MilliporeSigma Amicon Ultra-4

Amicon® Ultra-4 Centrifugal Filter Units are designed for the rapid concentration and purification of biological samples, including proteins, nucleic acids, and other macromolecules. These 4 mL devices feature a 3,000 Dalton molecular weight cut-off (MWCO) regenerated cellulose membrane, enabling efficient separation of molecules based on size.

Key features include:

• High recovery rates: Achieve retentate recovery exceeding 90%, ensuring minimal sample loss.
• Rapid processing: Vertical membrane design reduces concentration polarization, allowing spin times as short as 5 minutes.
• High concentration factors: Capable of concentrating samples up to 80- to 100-fold, facilitating downstream applications.
• User-friendly design: Translucent housing with volume gradations allows easy sample monitoring, while direct pipette access simplifies concentrate retrieval.
• Reliable performance: Heat-sealed membranes minimize extractables, and each unit undergoes 100% integrity testing.

These filter units are widely used in:

• Biotechnology: Essential for protein purification, concentration, and desalting processes.
• Molecular biology: Facilitates nucleic acid concentration and buffer exchange.
• Clinical diagnostics: Used in sample preparation for various diagnostic assays.

Commonly employed in university laboratories, biomedical research centres, and clinical environments, these devices have been integral to research and diagnostic workflows since their introduction.