WPI REMS-SYS Automated TEER Measurement System for High-Throughput Epithelial Barrier Analysis

The WPI REMS-SYS Automated TEER Measurement System is a robust, PC-controlled platform designed for high-throughput and precise measurement of transepithelial electrical resistance (TEER) in epithelial and endothelial monolayers cultured on 24- and 96-well HTS microplates. This system integrates an autosampler, WPI 54380 REMS interface box, and manufacturer-specific electrodes optimized for Corning HTS Transwell-24, Falcon HTS Multiwell-24, and Millicell-96 Cell Culture Insert Plates, enabling reproducible and accurate barrier integrity analysis essential in biotechnology, molecular diagnostics, and cellular permeability studies.

Key system features include:

• PC-controlled positioning and data acquisition via LabVIEW software, enabling customizable plate configuration and sample sequencing.
• Compatibility with high-content screening workflows for cell imaging and barrier function analysis in bioprocessing and biopharmaceutical production pipelines.
• Includes Dell PC with REMS software, NI DAQ PCI-6220 data acquisition card, autosampler, test plugs, and original installation media for seamless software integration.
• Supports manual and automated measurement modes with user-defined rinse locations to reduce cross-contamination risk during sequential well analyses.
• Enables rapid, accurate TEER measurements critical for evaluating epithelial tight junction integrity, widely adopted in synthetic biology research, gene editing validation, and drug permeability testing.

This system streamlines and standardizes TEER workflows, reducing operator variability and enhancing throughput in live-cell barrier assays crucial for molecular cloning workflows and clinical diagnostics involving cellular resistance quantification. The modular design facilitates integration into biomedical engineering labs focused on cell culture insert system analysis and fluorescence analysis applications.