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Beckman Coulter Multisizer 4e Electrical Sensing Zone Particle Size Analyzer

UsedBeckman CoulterParticle countersUnited States

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Particle Size Analysis Range:
Diameter: 0.2 — 1,600 µm Volume: 0.004 — 2.145 x 109 µm3 (fl)
Aperture Size
10 — 2,000 µm (nominal diameter)
Measurement range
Extended: 2 — 80% of aperture size Standard: 2 — 60% of aperture sizeessary.
Measurement linearity:
Diameter: ± 1% Volume: ± 3%
Dynamic range (accuracy)
Diameter: 1 : 40 (extended), 1 : 30 (standard) Volume: 1 : 64,000 (extended), 1 : 27,000 (standard)
All 24 specifications
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Specifications 24

Brands
Beckman Coulter
New/Used
Used
Particle Size Analysis Range:
Diameter: 0.2 — 1,600 µm Volume: 0.004 — 2.145 x 109 µm3 (fl)
Aperture Size
10 — 2,000 µm (nominal diameter)
Measurement range
Extended: 2 — 80% of aperture size Standard: 2 — 60% of aperture sizeessary.
Measurement linearity:
Diameter: ± 1% Volume: ± 3%
Dynamic range (accuracy)
Diameter: 1 : 40 (extended), 1 : 30 (standard) Volume: 1 : 64,000 (extended), 1 : 27,000 (standard)
Processor type
High speed signal digitalization processor
Number of pulses measured
Up to 525,000 per analysis
Resolution
User defined
Number of size classes
Up to 400 for display of any selected measurement range The number of classes and their width can be changed as needed
Pulse distribution data
X axis: time, registration sequence, pulse width Y axis: diameter, volume or voltage corresponding to pulse amplitude, pulse width, mean diameter, volume, or voltage corresponding to pules amplitude, average pulse width, pulse distribution by width
Particle size distribution data
X axis: diameter, volume, surface area Y axis: absolute number, percent content (%), number per ml, absolute volume, volume percentage (%), volume per ml, absolute surface area, surface area (%), surface area per ml
Sample registration mode: total number of particles
50 — 500,000 counts
Sample registration mode: number of particles and measurement of parameters
10 — 100,000 counts
Sample registration mode: time
0.1 — 999 seconds with at 10 ms increments Standard registration time is 10 — 90 seconds
Dosage system
The dosing pump with even suspension flow across the aperture and volume measurement, error – less than 0.5%
Electrolyte type:
Aqueous and non-aqueous electrolyte solutions compatible with glass, fluoropolymers, fluoroelastomers and stainless steel.
Aperture Current Range:
30 — 6,000 µA with 0.2 µA increments
Aperture current stability:
± 0.4% of set value
Polarity error
Less than 0.5%
Weight
100 lbs
Dimensions
24x44x19
Power
100 – 240 VAC; 50/60Hz, 210W

Product description

Real-time particle size counter measuring 0.2–1600 µm with digital pulse processing for biotech applications.

The Beckman Coulter Multisizer 4e is a high-precision electrical sensing zone particle size analyzer designed for real-time, multichannel particle counting and sizing. It operates over a broad particle diameter range from 0.2 µm to 1600 µm using apertures between 10 µm and 2000 µm, offering extended measurement range options of 2–80% of aperture size.

Key technical features include:

  • Digital pulse processing providing dynamic size measurement and up to 525,000 pulses per analysis for high-resolution data.
  • Measurement linearity with diameter accuracy of ±1% and volume accuracy of ±3%, critical for precise bioprocessing monitoring.
  • User-configurable resolution and up to 400 size classes for customized particle size distribution analysis.
  • Advanced software for calculating statistical parameters, enabling detailed evaluation of particle dynamics such as aggregation and cell-mediated responses—essential for molecular diagnostics and bioprocessing workflows.
  • Integrated Ez access system to monitor fluid levels and electrolyte status, assuring consistent operation during long biomanufacturing runs.
  • Support for both aqueous and non-aqueous electrolytes compatible with laboratory-grade materials such as glass and fluoropolymers.
  • Dosing system designed for even suspension flow with a measurement error below 0.5%, ensuring reproducible sample handling.

Dimensions are 24 x 44 x 19 inches, and the unit weighs 100 lbs, powered by 100–240 VAC, 50/60 Hz supply with 210 W consumption.

This instrument is widely used in biotechnology research, synthetic biology, cell imaging, and clinical diagnostics, particularly for applications requiring reliable, high-throughput particle size distribution data. It is critical in biopharmaceutical production pipelines and molecular cloning workflows to monitor and control particulate characteristics.

The Beckman Multisizer 4e complies with 21 CFR part 11, making it suitable for regulated environments in pharmaceutical and biotechnology industries. Its real-time data reporting and flexible data export options support comprehensive analysis for research professionals seeking advanced particle characterization solutions.

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Frequently asked questions

How long does laboratory equipment typically last?

With a service contract, ten to fifteen years is normal for most benchtop instruments. Detectors and pumps are the parts that wear first.

Can I get service for older equipment?

Often, yes. Verified suppliers frequently work with service partners converting the instrument. If applicable, we can list servicing options alongside the offer.

Where can I buy parts?

Ask a scientist through the request button. Parts are often available even when the instrument itself is discontinued.

What is the typical lead time for refurbished equipment?

Two to six weeks, depending on refurbishment scope and whether calibration is included.

Does laboratory equipment ship internationally?

We ship to 38 countries. Crating and customs handling are quoted with the instrument.

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Last updated 4 September 2026