Waters ACQUITY UPLC Column Heater/Cooler 10-90°C for High-Resolution Chromatography

The Waters ACQUITY UPLC Column Heater/Cooler is designed for ultra-performance liquid chromatography (UPLC) applications where precise temperature regulation is essential for high-resolution chromatographic separations. This advanced column heater/cooler supports columns with internal diameters ranging from 1.0 to 2.1 mm and lengths between 20 to 150 mm, compatible with single or serial column configurations.

Key technical features include:

• Temperature range of 10°C to 90°C for both heating and cooling, facilitating tight method control critical in molecular diagnostics and biotechnology research workflows.
• Integrated pre-column solvent heating and passive post-column cooling to stabilize solvent temperature, improving separation reproducibility and column lifetime.
• Lifetime usage tracking for each column assembly, supporting optimized maintenance for continuous bioprocessing or analytical pipelines.
• Supports columns up to 4.6 mm I.D. and 150 mm length, enabling flexibility for diverse chromatographic methods.
• Compact design weighing approximately 16.87 kg (37.2 lbs), suitable for benchtop laboratory environments focused on biopharmaceutical production pipelines and synthetic biology research.
• Includes high-sensitivity flow cells with pathlength options (10 mm and 25 mm), enhancing detection capability for trace analytes in clinical diagnostics and cell imaging biochemistry applications.

The device complies with harmonized code 902780, suitable for instruments used in physical and chemical analysis. This UPLC column heater/cooler is widely adopted in biotechnology and analytical chemistry laboratories, where thermal control is vital for reproducible retention times and method robustness. It seamlessly integrates within UPLC setups to enhance performance during temperature-dependent separation protocols, critical in applications such as gene editing validation, synthetic biology workflows, and biomolecular interaction studies.