Waters nanoACQUITY UPLC Sample Solvent Manager Chromatography System for High-Sensitivity Proteomics

The Waters nanoACQUITY UPLC Sample Solvent Manager Chromatography System is a compact, high-precision liquid chromatography setup tailored for advanced biotechnology and proteomics research, including peptide mapping and HDX-MS applications. This system integrates three core components on a mobile cart:

• Sample Manager (model 186016007) supporting two 384-well plates (768 samples) with ultra-low carryover (<0.005%), optimized for molecular diagnostics workflows requiring high sample integrity.
• Binary Solvent Manager (model 186016002) capable of handling up to four solvents for complex binary gradient elution profiles, essential in synthetic biology and biopharmaceutical production pipelines.
• Auxiliary Solvent Manager (model 186016021) providing low-flow solvent delivery for enhanced gradient precision.

Technical specifications include:

• Flow rate range: 200 nL/min to 100 μL/min, supporting nano-flow liquid chromatography critical in bioprocessing and live-cell analysis workflows.
• Maximum pressure limit: 15,000 psi, ensuring robust performance for high-resolution separations.
• Delay volume: less than 1 μL, minimizing sample dispersion and improving chromatographic efficiency.
• Injection volume capacity: 0.1 to 50 μL, suitable for low to moderate sample load ranges common in molecular cloning research.
• Temperature control range from 4°C to 40°C allows stable operating conditions aligned with protein and peptide stability requirements.

The system exhibits a red flow LED indicating a flow path or pressure-related error, requiring validation and calibration to restore full functionality. It is a pre-owned unit from a working lab environment with good cosmetic condition. This system is widely adopted in biotechnology laboratories focusing on molecular diagnostics, protein characterization, and synthetic biology research.

The modular design with solvent racks and the mobile system cart facilitates organized solvent management and operational flexibility. Validation and calibration services are recommended to ensure compliance with stringent biomanufacturing quality standards.

This UPLC system is an essential instrument for laboratories conducting high-sensitivity proteomics, biomedical engineering assays, and biomolecular separations that demand precision solvent delivery and low carryover performance.