Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap Mass Spectrometer for Native MS

The Thermo Scientific Q Exactive UHMR is a hybrid quadrupole-Orbitrap mass spectrometer optimized for native mass spectrometry and top-down protein analysis. Featuring ultra-high mass range resolution up to 200,000 at m/z 400 and a mass range extending from m/z 350 to 80,000, this instrument enables detailed characterization of intact protein assemblies and protein-ligand interactions critical in biotechnology, molecular diagnostics, and biopharmaceutical research.

Key technical specifications include:

• MS2 and pseudo-MS3 capabilities to enhance structural elucidations of macromolecules
• Internal mass accuracy of <1 ppm RMS ensures precise measurement essential for molecular cloning workflows and synthetic biology applications
• Scan rates of up to 12 Hz at a resolution of 12,500 allow efficient data acquisition for complex biological samples
• Dynamic range exceeding 5000:1 supports detection of low-abundance biomolecules in bioprocessing and biomedical engineering contexts

This mass spectrometer is integrated with an LC-MS-compatible modified side panel, ideal for seamless coupling with HPLC systems in proteomics and gene editing studies. Although the ion source cone assembly is missing, the unit powers on and is recommended for calibration and validation prior to use. Its ability to resolve small mass differences and perform native top-down analysis makes it widely adopted in synthetic biology research and biopharmaceutical production pipelines.

Compact yet robust, weighing approximately 218 kg, the Q Exactive UHMR is essential for laboratories focusing on live-cell imaging mass spectrometry, fluorescence analysis, and advanced protein characterization workflows. This instrument supports high sensitivity measurements from limited sample amounts, making it invaluable for detailed mechanistic studies of disease-related proteins and therapeutic compounds.