Thermo Scientific Q Exactive Orbitrap High-Resolution Hybrid Quadrupole Mass Spectrometer

The Thermo Scientific Q Exactive Orbitrap Mass Spectrometer is a high-performance hybrid quadrupole-Orbitrap system designed for advanced mass spectrometry applications in molecular diagnostics, bioprocessing, and synthetic biology research. It delivers exceptional resolving power of 140,000 and mass accuracy below 1 ppm (with internal calibration) over a broad mass range of 50–6,000 m/z. This system supports fast scan speeds up to 12 Hz, enabling high-throughput workflows essential for proteomics, metabolomics, and molecular cloning workflows.

Key features include:

• IonMax source with H-ESI II probe and ES071 Nanospray Flex Ion Source for efficient ionization in complex biological samples
• Rapid polarity switching in under 1 second at 35,000 resolution, facilitating simultaneous detection of positive and negative ions
• Multiple scan functions such as Selected Ion Monitoring (SIM) and Parallel Reaction Monitoring (PRM) for targeted quantitation and qualitative analyses
• In-source Collision-Induced Dissociation (CID) and Higher-energy Collisional Dissociation (HCD) fragmentation methods ideal for detailed structural elucidation
• Compatibility with EASY-nLC 1000 liquid chromatography system for seamless integration into biopharmaceutical production pipelines and live-cell metabolite profiling workflows
• Robust vacuum system ensuring optimal sensitivity and spectral quality

Widely adopted in biotechnology and clinical diagnostics laboratories, the Q Exactive Orbitrap supports applications ranging from gene editing validation to biomanufacturing quality control. This instrument is critical in molecular biology research requiring high resolution and mass accuracy, enabling scientists to achieve quantifiable certainty in complex sample characterization.