Thermo Fisher Scientific LTQ Orbitrap

Thermo Fisher's LTQ Orbitrap is a hybrid mass spectrometer that combines a linear ion trap with an Orbitrap mass analyzer, delivering exceptional mass accuracy and resolution. This instrument is designed for comprehensive analysis of complex biological samples, making it indispensable in various scientific domains.

Key features include:

• High mass resolution: Achieves up to 100,000 resolving power at m/z 400, enabling precise separation of closely related ions.
• Superior mass accuracy: Delivers mass accuracy within 2–3 ppm with external calibration and 1–2 ppm with internal calibration, ensuring reliable identification of analytes.
• Enhanced dynamic range: Capable of detecting low-abundance compounds amidst complex matrices, crucial for proteomics and metabolomics studies.
• Versatile fragmentation techniques: Supports collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD), facilitating detailed structural elucidation of molecules.

This system is widely applied in:

• Proteomics: Identifying and quantifying proteins in complex biological samples.
• Metabolomics: Profiling metabolites to understand biochemical pathways.
• Biotechnology: Advancing drug discovery and development through detailed molecular analysis.
• Environmental analysis: Detecting contaminants and pollutants with high sensitivity.

Commonly utilized in:

• University laboratories: Supporting cutting-edge research and education.
• Biotechnology companies: Enhancing product development and quality control processes.
• Clinical research facilities: Facilitating biomarker discovery and disease diagnostics.

Introduced in 2005, the LTQ Orbitrap has been a cornerstone in mass spectrometry, with its technology evolving to meet the growing demands of scientific research.