Thermo Fisher Scientific LTQ Orbitrap

The Thermo Fisher Scientific LTQ Orbitrap is a hybrid mass spectrometer that revolutionised analytical capabilities upon its release in 2005. Combining a linear ion trap with the innovative Orbitrap mass analyser, this instrument delivers exceptional mass accuracy and high-resolution data, making it indispensable for complex mixture analyses.

Key features include:

• Superior mass resolution and accuracy: Enables precise identification of compounds, even in intricate samples.
• High sensitivity: Detects low-abundance analytes, crucial for comprehensive proteomic and metabolomic studies.
• Versatile fragmentation techniques: Supports CID, PQD, and HCD, facilitating detailed structural elucidation.
• Dynamic range: Effectively analyses a broad spectrum of molecular species.

This mass spectrometer is widely utilised in:

• Proteomics: For protein identification, post-translational modification analysis, and protein interaction studies.
• Metabolomics: To profile metabolites and understand metabolic pathways.
• Biotechnology: Essential in bioprocessing, molecular diagnostics, and synthetic biology research.
• Pharmaceutical research: For drug discovery, development, and pharmacokinetics.

Commonly found in university laboratories, biomedical research centres, and clinical environments, the LTQ Orbitrap has been pivotal in advancing scientific understanding across multiple disciplines. While newer models have since been introduced, this instrument remains a benchmark in mass spectrometry, reflecting Thermo Fisher Scientific's commitment to innovation and excellence.